Frequency of dog erythrocyte antigen 1 1 in 4 breeds native to different areas in Turkey
Yazarlar (7)
Prof. Dr. Elif Ergul Ekiz Istanbul Üniversitesi, Türkiye
Prof. Dr. Murat Arslan Istanbul Üniversitesi, Türkiye
Prof. Dr. Mukaddes Ozcan Istanbul Üniversitesi, Türkiye
Prof. Dr. Guldal Inal Gultekin Istanbul Üniversitesi, Türkiye
Prof. Dr. Ozlem Yildiz Gulay Burdur Mehmet Akif Ersoy Üniversitesi, Türkiye
Prof. Dr. Turgut KIRMIZIBAYRAK Kafkas Üniversitesi, Türkiye
Urs Giger
University Of Pennsylvania School Of Veterinary Medicine, Amerika Birleşik Devletleri
University Of Pennsylvania School Of Veterinary Medicine, Amerika Birleşik Devletleri
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Veterinary Clinical Pathology | ||
| Dergi ISSN | 0275-6382 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2011 |
| Cilt / Sayı / Sayfa | 40 / 4 / 518–523 | DOI | 10.1111/j.1939-165X.2011.00370.x |
| Makale Linki | http://onlinelibrary.wiley.com/enhanced/doi/10.1111/j.1939-165X.2011.00370.x/ | ||
| UAK Araştırma Alanları |
Zootekni, Genetik ve Biyoistatistik
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| Özet |
| Background: Dog erythrocyte antigen (DEA) 1.1 is the most important RBC antigen clinically, as it is highly immunogenic and causes acute hemolytic transfusion reactions (HTR) in sensitized dogs. Objectives: The aims of this study were to determine the frequency of DEA 1.1 expression in 4 Turkish dog breeds, and to estimate the potential risk of HTR when blood from a DEA 1.1-positive donor is administered to a DEA 1.1-negative recipient following sensitization by a prior mismatched transfusion. Methods: EDTA blood samples (n = 178) were typed for DEA 1.1 using a commercial gel-column agglutination test (ID-Gel-Test Canine DEA 1.1). Probabilities of sensitization and risk of an HTR were calculated. Results: The frequency of positivity for DEA 1.1 among Kars (n = 59), Kangal (n = 53), Akbash (n = 50), and Catalburun (n = 16) breeds was 71.2%, 67.9%, 60.0%, and 50.0%, respectively. Potential risk for occurrence of an HTR after administration of blood from a dog of the same breed ranged from 12.5% to 14.8%, whereas HTR induced by blood of a dog from a different breed ranged from 7.2% to 25.3%. Conclusions: The frequency of DEA 1.1-positive dogs among 4 Turkish breeds is high compared with that of most other breeds previously surveyed. The predicted risk of both sensitization and occurrence of DEA 1.1-related HTR following transfusion between dogs of either the same or different Turkish breeds was considerable. Although few dogs are transfused ≥4 days after the first transfusion, we recommend that (1) all donors and recipients be typed for DEA 1.1, (2) DEA 1.1-negative recipients receive only DEA 1.1-negative blood, and (3) blood be cross-matched prior to transfusing any dog ≥4 days after the first transfusion. These guidelines are also applicable to other breeds and countries. © 2011 American Society for Veterinary Clinical Pathology. |
| Anahtar Kelimeler |
| Blood type | DEA | Hemolytic reaction | Sensitization | Transfusion medicine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |
| Scopus | 20 |