Pregnancy outcomes of antibody negative and untreated subclinical hypothyroidism
Yazarlar (4)
Burcu Dinçgez
Türkiye
Türkiye
Doç. Dr. Ülkü Ayşe TÜRKER ARAS Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer Temür Türkiye
Emin Üstünyurt
Sağlık Bilimleri Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Obstetrics and Gynaecology Research (Q3) | ||
| Dergi ISSN | 1341-8076 Dergi Bilgileri (2019) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2019 |
| Kabul Tarihi | 23-12-2018 | Yayınlanma Tarihi | 22-01-2019 |
| Cilt / Sayı / Sayfa | 45 / 4 / 810–816 | DOI | 10.1111/jog.13925 |
| Makale Linki | http://dx.doi.org/10.1111/jog.13925 | ||
| UAK Araştırma Alanları |
Kadın Hastalıkları ve Doğum
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| Özet |
| AbstractAimSubclinical hypothyroidism is thought to be associated with adverse pregnancy outcomes but the data is conflicting and generally depends on antibody positivity and treatment. We evaluated the pregnancy outcomes in Turkish population with untreated, antibody negative subclinical hypothyroidism for the first time.MethodsWe searched for 30 015 patients between January 2016 and May 2017 retrospectively. Finally, a total of 930 pregnant women with untreated, antibody negative subclinical hypothyroidism and 7986 controls were included. Demographic characteristics, laboratory findings and pregnancy outcomes, including pregnancy loss, impaired glucose tolerance, gestational diabetes, hypertensive disorders of pregnancy, preterm birth, neonatal intensive care unit admission, placenta previa and abruption, cesarean delivery, low birthweight, Apgar score <7 and premature rupture of membranes were recorded.ResultsDemographic and laboratory characteristics were similar between two groups except thyroid stimulating hormone levels and previous uterine surgery rates. Subclinical hypothyroidism group had an increased risk of pregnancy loss (odds ratio [OR] 2.583; 95% confidence interval [CI] 1.982–3.365; P < 0.001), impaired glucose tolerance (OR 1.952; 95% CI 1.450–2.627; P < 0.001), hypertensive disorders of pregnancy (OR 1.476; 95% CI 1.113–1.923; P = 0.004), neonatal intensive care unit admission (OR 1.620; 95% CI 1.084–2.420; P = 0.019), placenta previa (OR 12.581; 95% CI 5.046–31.363; P < 0.001) and cesarean delivery (OR 1.263; 95% CI 1.091–1.462; P = 0.002).ConclusionSubclinical hypothyroidism has worse pregnancy outcomes as compared to euthyroid pregnant women even in antibody negativity. Therefore, we suggest that all pregnant women should routinely be screened in their first antenatal visits for thyroid functions. |
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BM Sürdürülebilir Kalkınma Amaçları
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