| Yazarlar (10) |
Muhammed Süleymanoğlu
Türkiye |
|
Cengiz Burak
Türkiye |
|
Ayça Gümüşdağ
Türkiye |
|
Murat Çap
Türkiye |
|
Ayhan Şenol
Türkiye |
|
Şerif Hamideyin
Kafkas Üniversitesi, Türkiye |
|
Ezgi Güzel
Türkiye |
Prof. Dr. İbrahim RENCÜZOĞULLARI
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Yavuz KARABAĞ
Kafkas Üniversitesi, Türkiye |
|
Metin Çağdaş
Türkiye |
| Özet |
| Peripheral artery disease (PAD) is part of the systemic atherosclerotic process that is highly associated with cardiovascular diseases. Despite successful endovascular treatment (EVT) strategies, mortality and morbidity rates still remain higher in PAD patients. C-reactive protein (CRP) and albumin are biomarkers of inflammation and malnutrition that play key roles in the progression of peripheral arterial disease. In this study, we aimed to investigate the relationship between CRP-to-albumin ratio (CAR) and mortality and amputation-free survival in patients with PAD after successful EVT. Our study enrolled 149 consecutive patients who underwent EVT on atherosclerotic obstruction of iliac, femoral, popliteal and/or below-knee arteries with the clinical features of PAD and/or chronic limb-threatening ischaemia between January 2015 and January 2020. Clinical and prognostic follow-up of patients had been done at the outpatient clinic and were collected from institution's medical records. The mean follow-up period was 22 months (14-40). All-cause mortality and amputation rates of patients in the high CAR group were significantly higher than those in the low CAR group (21.3% vs. 6.8% and 18.7% vs. 5.4%, respectively). Kaplan-Meier survival analysis showed significantly better survival for patients in the low CAR group (log-rank = 0.0058). In multivariate logistic regression analysis, CAR was found to be an independent predictor of amputation and all-cause mortality even after adjusting for other confounding risk factors. ROC curve analysis revealed the optimal cut-off value of CAR for predicting all-cause mortality and amputation to be >1.476 with a sensitivity of 48.5% and specificity of 94.0%. The inflammatory state reflected by CAR levels was strongly associated with all-cause mortality and amputation after EVT in patients with PAD. Furthermore, CAR was found to be an independent predictor of these clinical outcomes after adjusting for other clinically associated parameters. |
| Anahtar Kelimeler |
| C-reactive protein | albumin | peripheral arterial disease | endovascular treatment | amputation | mortality |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Vascular |
| Dergi ISSN | 1708-5381 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2022 |
| Cilt No | 30 |
| Sayı | 3 |
| Sayfalar | 481 / 489 |
| Doi Numarası | 10.1177/17085381211025172 |
| Makale Linki | http://dx.doi.org/10.1177/17085381211025172 |
| Atıf Sayıları | |
| WoS | 11 |
