Insulin-like growth factor-1 levels predict myocardialinjury and infarction after elective percutaneous coronaryintervention: an optical coherence tomography study
Yazarlar (7)
Onur Taşar
Türkiye
Gonenc Kocabay
Türkiye
Prof. Dr. Yavuz KARABAĞ
Kafkas Üniversitesi, Türkiye
Arzu Kalaycı Karabay
Türkiye
Can Yücel Karabay
Sağlık Bilimleri Üniversitesi, Türkiye
Sedat Kalkan
Türkiye
Cevat Kırma
Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Postepy w Kardiologii Interwencyjnej | ||
| Dergi ISSN | 1734-9338 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2020 |
| Cilt / Sayı / Sayfa | 16 / 2 / 162–169 | DOI | 10.5114/aic.2020.96059 |
| Makale Linki | https://www.termedia.pl/Insulin-like-growth-factor-1-levels-predict-myocardial-injury-and-infarction-after-elective-percutaneous-coronary-intervention-an-optical-coherence-tomography-study,35,40859,1,1.html | ||
| Özet |
| Periprocedural myocardial necrosis, which can range from a low level elevation of cardiac biomarkers to a large myocardial infarction (MI), is a common complication after percutaneous coronary intervention (PCI). We hypothesized that insulin-like growth factor-1 (IGF-1) levels may play a protective role in myocardial injury after coronary stent placement and aimed to investigate the relationship between IGF-1 levels and plaque characteristics assessed by optical coherence tomography (OCT). Between May 2015 and December 2015 we prospectively enrolled 74 patients with stable angina pectoris in whom single de novo coronary artery stenosis was present. PCI was performed according to standard methods. OCT was applied to all patients. TnT was analyzed at admission, before PCI and at 6, 12, 24 and 48 h after PCI. Serum IGF-1 was measured prior to PCI. A total of 25 (33.7%) patients had periprocedural myocardial injury or type 4a myocardial infarction, and 49 (66.2%) patients had no events. IGF-1 level and reference intimal thickness, medial thickness, and plaque fibrous cap thickness in OCT had strong correlations ( = 0.88, 0.80 and 0.88 respectively, < 0.001). IGF-1 was an independent predictor of periprocedural myocardial injury or type 4a MI in univariate (OR = 0.929, 95% CI: 0.895-0.964, < 0.001) and multivariate regression analysis (OR = 0.757, 95% CI: 0.575-0.998, = 0.04). Based on ROC analysis, the best cut-off value of IGF-1 for predicting periprocedural myocardial injury or type 4a myocardial infarction was 144.5 ng/ml, with a maximum sensitivity of 88% and specificity of 77.6% (AUC = 0.80, 95% CI: 0.69-0.88, < 0.0001). The results from this study indicate that low IGF-1 levels are associated with plaque instability assessed by OCT. Low IGF-1 levels may identify patients who are at increased risk for periprocedural myocardial injury/infarction. |
| Anahtar Kelimeler |
| insulin-like growth factor-1 levels | myocardial injury | percutaneous coronary intervention |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |