| Yazarlar (11) |
Tolga Sinan Güvenç
Türkiye |
|
Hatice Betül Erer
Türkiye |
|
Şeref Kul
İstanbul Medeniyet Üniversitesi, Türkiye |
|
Gökhan Perinçek
Türkiye |
|
Sami İlhan
Türkiye |
|
Nurten Sayar
Marmara Üniversitesi, Türkiye |
|
Binnaz Zeynep Yıldırım
Türkiye |
|
Coşkun Doğan
Türkiye |
Doç. Dr. Yavuz KARABAĞ
Kafkas Üniversitesi, Türkiye |
|
Bahattin Balcı
Kafkas Üniversitesi, Türkiye |
|
Mehmet Eren
Türkiye |
| Özet |
| Pulmonary vasculature is affected in patients with chronic pulmonary obstructive disease (COPD). As a result of increased pulmonary resistance, right ventricular morphology and function are altered in COPD patients. High altitude and related hypoxia causes pulmonary vasoconstriction, thereby affecting the right ventricle. We aimed to investigate the combined effects of COPD and altitude-related chronic hypoxia on right ventricular morphology and function. Forty COPD patients living at high altitude (1768 m) and 41 COPD patients living at sea level were enrolled in the study. All participants were diagnosed as COPD by a pulmonary diseases specialist depending on symptoms, radiologic findings and pulmonary function test results. Detailed two-dimensional echocardiography was performed by a cardiologist at both study locations. Oxygen saturation and mean pulmonary artery pressure were higher in the high altitude group. Right ventricular end diastolic diameter, end systolic diameter, height and end systolic area were significantly higher in the high altitude group compared to the sea level group. Parameters of systolic function, including tricuspid annular systolic excursion, systolic velocity of tricuspid annulus and right ventricular isovolumic acceleration were similar between groups, while fractional area change was significantly higher in the sea level groups compared to the high altitude group. Indices of diastolic function and myocardial performance index were similar between groups. An increase in mean pulmonary artery pressure and right ventricular dimensions are observed in COPD patients living at high altitude. Despite this increase, systolic and diastolic functions of the right ventricle, as well as global right ventricular performance are similar in COPD patients living at high altitude and sea level. Altitude-related adaptation to chronic hypoxia could explain these findings. |
| Anahtar Kelimeler |
| Chronic obstructive pulmonary disease | Right ventricle | High altitude | Echocardiography |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Heart, Lung and Circulation |
| Dergi ISSN | 1443-9506 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2013 |
| Cilt No | 22 |
| Sayı | 1 |
| Sayfalar | 31 / 37 |
| Doi Numarası | 10.1016/j.hlc.2012.08.004 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1443950612012115 |
| Atıf Sayıları | |
| WoS | 11 |
