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Human Papilloma Virus‐11 DNA Detection by Graphene‐PAMAM Modified Impedimetric CRISPR‐dCas9 Biosensor    
Yazarlar
Mehmet Utku Mumcu
Türkiye
Hilmiye Deniz Ertuğrul Uygun
Dokuz Eylül Üniversitesi, Türkiye
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Türkiye
Özet
Human Papilloma Virus-11 (HPV-11) is leads to condylomata acuminata (CA), which has commonly known as genital wards that global widespread incidence of 160 to 289 cases per year. In the first-time literature, we detect HPV-11 DNA by using dCas9 modified graphene oxide-PAMAM modified electrodes, impedimetrically. Chronoimpedimetric detection was facilitated the biosensor response time optimization of HPV-11 DNA in 5 minutes. The biosensor has ability to analyze HPV-11 DNA between 50 pM and 1000 pM with good linearity, sensitivity and selectivity. Moreover, we tested our biosensor in real samples matrix by considering recovery of the samples.
Anahtar Kelimeler
biosensor | CRISPR | dCas9 | HPV-11 | chronoimpedance
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı ELECTROANALYSIS
Dergi ISSN 1040-0397
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q3
Makale Dili İngilizce
Basım Tarihi 05-2022
Cilt No 34
Sayı 5
Sayfalar 830 / 834
Doi Numarası 10.1002/elan.202100536
Makale Linki http://dx.doi.org/10.1002/elan.202100536