A novel biorecognition receptor Citropin-A modified impedimetric biosensor for detection of LNCaP prostate cancer cells
Yazarlar (4)
Cemrehan Fedacı Ege University Medical School, Türkiye
Öğr. Gör. Hilmiye Deniz Ertuğrul Uygun Dokuz Eylül Üniversitesi, Türkiye
Doç. Dr. Zihni Onur UYGUN Kafkas Üniversitesi, Türkiye
Prof. Dr. Yasemin Akçay Ege Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Analytical Biochemistry (Q2) | ||
| Dergi ISSN | 0003-2697 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2022 |
| Cilt / Sayı / Sayfa | 652 / 1 / 114772–0 | DOI | 10.1016/j.ab.2022.114772 |
| Makale Linki | http://dx.doi.org/10.1016/j.ab.2022.114772 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| In this study, Citropin-A (Cit-A) as a biorecognition receptor was used for the first time to develop electrochemical impedance spectroscopy (EIS) based biosensor for the detection of Lymph Node Carcinoma of the Prostate (LNCaP) cancer cells. The biosensor was engineered by modification of a gold electrode (AuE) with cysteamine (Cys), Poliamidoamin (PAMAM (G4)) dendrimers, avidin, and biotinylated Cit-A, respectively. The detection time of the LNCaP cells was determined as 300 s by chronoimpedance (CI). Chronoimpedance also provided an exact detection time to avoid non-specific adsorptions. The biosensor showed good linearity between 1500 cells/L and 12000 cells/L, limit of detection (LOD), and limit of quantification (LOQ) values were 518 cells/L and 1570 cells/L, respectively. |
| Anahtar Kelimeler |
| Antimicrobial peptide | Biosensor | Chronoimpedance | Impedance | Prostate cancer |
Science Direct
A novel biorecognition receptor Citropin-A modified impedimetric biosensor for detection of LNCaP prostate cancer cells
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 6 |
| Google Scholar | 5 |