A Novel Chronoimpedimetric Cytosine Modified Molecularly Imprinted Sensor for Label-Free Detection of 8-Hydroxydeoxyguanosine in Urine Samples
Yazarlar (3)
Öğr. Gör. Hilmiye Deniz Ertuğrul Uygun Dokuz Eylül Üniversitesi, Türkiye
Doç. Dr. Zihni Onur UYGUN Kafkas Üniversitesi, Türkiye
Prof. Dr. Ferhan Girgin Sağın Ege Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of the Electrochemical Society (Q1) | ||
| Dergi ISSN | 0013-4651 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2022 |
| Cilt / Sayı / Sayfa | 169 / 10 / 107501–0 | DOI | 10.1149/1945-7111/ac9557 |
| Makale Linki | http://dx.doi.org/10.1149/1945-7111/ac9557 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| First time in the literature, we imprinted 8-hydroxyguanosine (8OHG) to engineer an impedimetric sensor on a polymer from three different main non-covalent structures. Considering the chemical structure of the molecule and its potential non-covalent bonding behaviors, we designed a special electrode with molecular imprinting technology (MIT). Therefore, 8OHG, which serves as an important biomarker of oxidative stress, was imprinted on an electrode to form an 8OHG sensor. In this imprinting method, firstly, a gold electrode was modified with Cytosine-1yl-acetic acid (CAA) to increase selectivity and form DNA hydrogen bond-like structures. Afterward, pyrrole and aminophenyl boronic acid monomers were polymerized from three different points by electropolymerization, and a selective and sensitive sensor technology was developed. 8OHG measurement was carried out impedimetrically in six minutes (R2 value ... |
| Anahtar Kelimeler |
| 8-hydroxyguanosine | chronoimpedance | impedance | molecular imprinting | oxidant stress | sensor |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 2 |