| Yazarlar |
Berin Özdalgıç
Doğuş Üniversitesi, Türkiye |
|
Münire Gül
Türkiye |
Doç. Dr. Zihni Onur UYGUN
Kafkas Üniversitesi, Türkiye |
|
Nazente Atçeken
Türkiye |
|
Savaş Taşoğlu
Türkiye |
| Özet |
| Human tear film, with a flow rate of 1–3 µL/min, is a rich bodily fluid that transmits a variety of metabolites and hormones containing proteins, lipids and electrolytes that provide clues about ocular and systemic diseases. Analysis of disease biomarkers such as proteins, mRNA, enzymes and cytokines in the tear film, collected by noninvasive methods, can provide significant results for sustaining a predictive, preventive and personalized medicine regarding various diseases such as glaucoma, diabetic retinopathy, keratoconus, dry eye, cancer, Alzheimer’s disease, Parkinson’s disease and COVID-19. Electrochemical impedance spectroscopy (EIS) offers a powerful technique for analyzing these biomarkers. EIS detects electrical equivalent circuit parameters related to biorecognition of receptor–analyte interactions on the electrode surface. This method is advantageous as it performs a label-free detection and allows the detection of non-electroactive compounds that cannot be detected by direct electron transfer, such as hormones and some proteins. Here, we review the opportunities regarding the integration of EIS into tear fluid sampling approaches. |
| Anahtar Kelimeler |
| biosensing | ocular diagnosis | systemic disease diagnosis | tear fluid | electrochemical impedance spectroscopy |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BIOSENSORS-BASEL |
| Dergi ISSN | 2079-6374 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2022 |
| Cilt No | 12 |
| Sayı | 10 |
| Sayfalar | 1 / 21 |
| Doi Numarası | 10.3390/bios12100827 |
| Makale Linki | http://dx.doi.org/10.3390/bios12100827 |
| Atıf Sayıları | |
| WoS | 4 |
| SCOPUS | 5 |
| Google Scholar | 9 |
