Detection of circulating prostate cancer cells via prostate specific membrane antigen by chronoimpedimetric aptasensor
Yazarlar (2)
Doç. Dr. Zihni Onur UYGUN Kafkas Üniversitesi, Türkiye
Prof. Dr. Ferhan Girgin Sağın Ege Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Turkish Journal of Biochemistry (Q4) | ||
| Dergi ISSN | 0250-4685 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2021 |
| Cilt / Sayı / Sayfa | 46 / 6 / 631–637 | DOI | 10.1515/TJB-2021-0056 |
| Makale Linki | http://dx.doi.org/10.1515/tjb-2021-0056 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Objectives Sensitive and accurate techniques for early detection of prostate cancer, which has a good chance for successful treatment if detected early, are of utmost value. Our aim is to develop a sensitive chronoimpedimetric biosensor for detection of circulating prostatic tumor cells (CTCs) with an aptamer selective for prostate specific membrane antigen (PSMA). Methods Thiolated PSMA-specific aptamer was immobilized on the gold nanoparticle modified carbon screen-printed electrodes. After characterization with cyclic voltammetry and electrochemical impedance spectrometry, scanning electron microscopy and atomic force microscopy studies were conducted to confirm the modifications. LNCaP cells (androgen-sensitive human prostate adenocarcinoma cells), were then added to the serum samples and chronoimpedimetric detection of CTCs in samples were performed. Results Our study showed one ... |
| Anahtar Kelimeler |
| Aptasensor | Chronoimpedance | CTC | Liquid biopsy | Prostate cancer | PSMA |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 9 |
| Scopus | 14 |
| Google Scholar | 13 |