A novel, ultra sensible biosensor built by layer-by-layer covalent attachment of a receptor for diagnosis of tumor growth
Yazarlar (2)
Doç. Dr. Zihni Onur UYGUN Kafkas Üniversitesi, Türkiye
Mustafa Kemal Sezgintürk Namık Kemal Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Analytica Chimica Acta | ||
| Dergi ISSN | 0003-2670 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2011 |
| Cilt / Sayı / Sayfa | 706 / 2 / 343–348 | DOI | 10.1016/j.aca.2011.08.044 |
| Makale Linki | http://dx.doi.org/10.1016/j.aca.2011.08.044 | ||
| Özet |
| In the presented research, a novel, ultra sensitive biosensor for the impedimetric detection of vascular endothelial growth factor (VEGF) is introduced. The human vascular endothelial growth factor receptor 1 (VEGF-R1, Flt-1) was used as a biorecognition element for the first time. The immobilization of VEGF-R1 on glassy carbon electrodes was carried out using layer-by-layer covalent attachment of VEGF-R1. The electrochemical properties of the layers constructed on the electrodes were characterized by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The differences in electron transfer resistance (Ret) between the working solution and the biosensor surface, recorded by the redox probe K3[Fe(CN)6]/K4[Fe(CN)6], confirmed the binding of VEGF to VEGF-R1. The new biosensor allowed a detection limit of 100fgmL−1 with a linear range of 100–600fgmL−1 to be obtained. The biosensor … |
| Anahtar Kelimeler |
| Biosensor | Cancer | Electrochemical impedance spectroscopy | Receptor-1 | Tumor growth | Vascular endothelial growth factor |
Science Direct
A novel, ultra sensible biosensor built by layer-by-layer covalent attachment of a receptor for diagnosis of tumor growth
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 28 |
| Web of Science | 20 |
| Scopus | 22 |