Effect of dexpanthenol on colonic anastomosis healing in rats
Yazarlar (8)
Prof. Dr. Celal Şahin ERMUTLU
Kafkas Üniversitesi, Türkiye
Prof. Dr. Ekin Emre ERKILIÇ
Kafkas Üniversitesi, Türkiye
Prof. Dr. Engin KILIÇ
Kafkas Üniversitesi, Türkiye
Prof. Dr. Ali Haydar KIRMIZIGÜL
Kafkas Üniversitesi, Türkiye
Prof. Dr. Serpil DAĞ
Kafkas Üniversitesi, Türkiye
Prof. Dr. Metin ÖĞÜN
Kafkas Üniversitesi, Türkiye
Prof. Dr. Vedat BARAN
Kafkas Üniversitesi, Türkiye
Prof. Dr. Oğuz MERHAN
Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice | ||
| Dergi ISSN | 0025-8628 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2018 |
| Cilt / Sayı / Sayfa | 74 / 11 / 702–707 | DOI | 10.21521/mw.6135 |
| Makale Linki | http://www.medycynawet.edu.pl/images/stories/pdf/pdf2018/112018/2018116135.pdf | ||
| Özet |
| The purpose of this study was to perform the clinical, histopathologic and biochemical evaluation of the effects of intraperitoneally (IP) administered dexpanthenol (dxp) on colonic anastomosis healing in rats. The study was conducted on a total of 28 rats divided into four groups comprising seven rats each. Group I was designated as the control group, group II as the dxp group, group III as the anastomosis group, and group IV as the anastomosis + dxp group. The groups were compared in terms of intestinal bursting pressure, adhesion formation, nitric oxide (NO) and malondialdehyde (MDA) levels, total antioxidant capacity (TAC) and total oxidant capacity (TOC) in blood and intestinal homogenates, as well as histopathologic findings. Dxp decreased adhesion formation (6 rats in group III and 4 rats in group IV). Mean bursting pressures were higher in the dxp groups than in the other groups (group II = 254.3 ± 42.1 mmHg, group IV = 109.3 ± 34.5 mmHg). Moreover, there was a remarkable decrease in the levels of NO and MDA and in blood oxidative stress parameters in the dxp groups. The results suggest that dxp increased intestinal bursting pressure by accelerating healing in the anastomosis line and decreased adhesion formation, positively affecting healing. Dexpanthenol, which was found to have positive effects in the experimental rat model, can be introduced into clinical practice. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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