Synthesis, anticancer activity and molecular modeling study of novel substituted triazole linked tetrafluoronaphthalene hybrid derivatives
Yazarlar (2)
Doç. Dr. Musa ERDOĞAN Kafkas Üniversitesi, Türkiye
Ferah Cömert Önder Çanakkale Onsekiz Mart Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Biomolecular Structure and Dynamics (Q3) | ||
| Dergi ISSN | 0739-1102 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2024 |
| Cilt / Sayı / Sayfa | 42 / 18 / 9767–9786 | DOI | 10.1080/07391102.2023.2252914 |
| Makale Linki | https://doi.org/10.1080/07391102.2023.2252914 | ||
| Özet |
| To create some novel anticancer molecules, a library of novel series of various triazoles linked to the hydroxyl group of 5,6,7,8-tetrafluoronaphthalen-1-ol (3) was designed and synthesized via CuAAC reaction ‘Click Chemistry’ of tetrafluoronaphthalene based terminal alkyne with substituted organic azides. The structural characterizations of the targeted Click products 9–18 were confirmed by FTIR, 1H NMR, 19F NMR, 13C NMR and HRMS spectroscopy. Synthesized compounds were tested in two triple negative breast cancer (TNBC) cell lines to understand their anticancer potentials. According to our findings, compounds 14 and 13 showed high cytotoxicity in BT549 cells at 20 μM and 30 μM, respectively. Moreover, these compounds blocked the migration of BT549 cells. In the MDA-MB-231 cell line, compound 18 exhibited high cytotoxicity and can block cell migration for 24 h. Molecular docking study with … |
| Anahtar Kelimeler |
| ADMET | anticancer activity | Click chemistry | molecular docking | molecular dynamics (MD) simulation | tetrafluoronaphthalene | triazole |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 12 |
| Scopus | 11 |