Sulfonamide derivatives with benzothiazole scaffold: Synthesis and carbonic anhydrase I–II inhibition properties
Yazarlar (7)
Doç. Dr. Erbay KALAY
Kafkas Üniversitesi, Türkiye
Serpil Gerni
Neslihan Balcı
Türkiye
Doç. Dr. Feyzi Sinan TOKALI
Kafkas Üniversitesi, Türkiye
Osman Nuri Aslan
Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (Q3) | ||
| Dergi ISSN | 0885-4513 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2024 |
| Cilt / Sayı / Sayfa | 71 / 1 / 223–231 | DOI | 10.1002/bab.2534 |
| Makale Linki | https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/bab.2534 | ||
| Özet |
| The secondary sulfonamide derivatives containing benzothiazole scaffold (1-10) were synthesized to determine their inhibition properties on two physiologically essential human carbonic anhydrases isoforms (hCAs, EC, 4.2.1.1), hCA I, and hCA II. The inhibitory effects of the compounds on hCA I and hCA II isoenzymes were investigated by comparing their IC and K values. The K values of compounds (1-10) against hCA I and hCA II are in the range of 0.052 ± 0.022-0.971 ± 0.280 and 0.025 ± 0.010-0.682 ± 0.335, respectively. Some of these inhibited the enzyme more effectively than the standard drug, acetazolamide. In particular, compounds 5 and 4 were found to be most effective on hCA I and hCA II. |
| Anahtar Kelimeler |
| benzothiazole moiety | human carbonic anhydrase I | human carbonic anhydrase II | inhibition | secondary sulfonamide derivatives |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 9 |