| Yazarlar |
Cansu Ozturk
|
Doç. Dr. Erbay KALAY
Kafkas Üniversitesi |
|
Serpil Gerni
|
|
Neslihan Balci
|
|
Feyzi Sinan Tokali
|
|
Osman Nuri Aslan
|
|
Emrah Polat
|
| Özet |
| The secondary sulfonamide derivatives containing benzothiazole scaffold (1-10) were synthesized to determine their inhibition properties on two physiologically essential human carbonic anhydrases isoforms (hCAs, EC, 4.2.1.1), hCA I, and hCA II. The inhibitory effects of the compounds on hCA I and hCA II isoenzymes were investigated by comparing their IC and K values. The K values of compounds (1-10) against hCA I and hCA II are in the range of 0.052 ± 0.022-0.971 ± 0.280 and 0.025 ± 0.010-0.682 ± 0.335, respectively. Some of these inhibited the enzyme more effectively than the standard drug, acetazolamide. In particular, compounds 5 and 4 were found to be most effective on hCA I and hCA II. |
| Anahtar Kelimeler |
| benzothiazole moiety | human carbonic anhydrase I | human carbonic anhydrase II | inhibition | secondary sulfonamide derivatives |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY |
| Dergi ISSN | 0885-4513 |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2024 |
| Cilt No | 71 |
| Sayı | 1 |
| Sayfalar | 223 / 231 |
| Doi Numarası | 10.1002/bab.2534 |
| Atıf Sayıları |
