The usability of MCP-1, fetuin-A, TAS, and TOS levels in the diagnosis of acute myocardial infarction
Yazarlar (8)
Handan Çiftçi
Türkiye
Türkiye
Doç. Dr. Hüseyin Fatih GÜL Kafkas Üniversitesi, Türkiye
Ömer Çanacık
Türkiye
Türkiye
Doç. Dr. Turgut Dolanbay Türkiye
Emre Karslı Türkiye
D Erçin
Doç. Dr. Levent ŞAHİN Kafkas Üniversitesi, Türkiye
Prof. Dr. Mahmut KARAPEHLİVAN Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES (Q2) | ||
| Dergi ISSN | 1128-3602 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2023 |
| Cilt / Sayı / Sayfa | 27 / 10 / 4481–4491 | DOI | – |
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Our aims were to determine whether the levels of plasma monocyte chemotactic protein-1 (MCP-1), fetuin-A, serum total antioxidant status (TAS), and serum total oxidant status (TOS) are cardiac biomarkers and to clarify their relationship with each other in acute myocardial infarction (AMI). The study included 90 participants: 60 patients with AMI [30 with and 30 without ST-segment elevation myocardial infarction (STEMI)] and 30 cardiac patients without AMI. The diagnostic values of serum Hs-cTnT, MCP-1, fetuin-A, TAS, and TOS levels in predicting AMI were evaluated statistically. Median levels of MCP-1 [120.10 ng/L (interquartile range: 76.94-230.54 ng/L)] and TOS [2.89 U/MI (IQR: 2.31-3.94 U/Ml)] were statistically higher, and median levels of fetuin-A [433.52 mg/L (IQR: 387.89-584.49 mg/L)] and TAS (3.10 ± 0.86 U/mL) were lower in patients with AMI than in controls. The parameter with the area under the curve (0.815), sensitivity (73.3%), and specificity (66.7%) closest to those of Hs-cTnT was fetuin-A, followed by MCP-1, TOS, and TAS, respectively. A one-unit increase in MCP-1 levels increased the probability of AMI by 1.023 times (p = 0.002). A one-unit increase in fetuin-A levels decreased the probability of AMI by 0.995 times (p = 0.003). A one-unit increase in serum TOS levels was 1.29 times more characteristic of STEMI than of NSTEMI (p = 0.044). MCP-1, oxidative stress parameters, and fetuin-A might support Hs-cTnT levels in the early diagnosis of AMI. Fetuin-A and MCP-1 levels may be independent risk factors for AMI, whereas TOS could be used to distinguish STEMI from NSTEMI. |
| Anahtar Kelimeler |
| Myocardial infarction | Oxidative stress parameter | Cardiac biomarker |
