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The relationship between estrogen receptors and microtubule dynamics in post-menopausal rat brain   
Yazarlar
Aksak Karamese Selina
Doç. Dr. Murat KARAMEŞE
Kafkas Üniversitesi
Karakus Emre
Ismail Malkoc
Unal Bunyami
Gundogdu Cemal
Özet
Estrogen is one of the most important regulators of neuron function. There is a broad consensus that a loss of estrogen is associated with neurodegeneration in the hippocampus which leads to cognitive impairment. Hematopoietic-Pbx-interaction-protein (HPIP) is a novel scaffolding protein which interacts with microtubules and estrogen receptors. In this study, we investigated the presence and role of HPIP in hippocampal neurons and examined the relationship between estrogen receptors and microtubule damage in post-menopausal rat brains.
Anahtar Kelimeler
Axonal neurodegeneration,Estrogen receptors,HPIP,Microtubule,Ovariectomy
Makale Türü Özgün Makale
Makale Alt Türü ESCI dergilerinde yayımlanan tam makale
Dergi Adı ACTA HISTOCHEMICA
Dergi ISSN 0065-1281
Makale Dili İngilizce
Basım Tarihi 1-2015
Cilt No 117
Sayı 8
Sayfalar 747 / 751
Doi Numarası 10.1016/j.acthis.2015.08.005