| Yazarlar (15) |
Akın Yakan
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Hüseyin Özkan
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Ufuk Kaya
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Hasan Hüseyin Keçeli
Türkiye |
|
Sevda Dalkıran
|
|
İrem Karaaslan
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Necmettin Ünal
Türkiye |
|
Aytaç Akçay
Ankara Üniversitesi, Türkiye |
|
Korhan Arslan
Türkiye |
|
Bilal Akyüz
Erciyes Üniversitesi, Türkiye |
|
Güven Güngör
Bingöl Üniversitesi, Türkiye |
|
Baran Çamdeviren
|
Dr. Öğr. Üyesi Mehmet KÜÇÜKOFLAZ
Kafkas Üniversitesi, Türkiye |
|
Savaş Sarıözkan
Erciyes Üniversitesi, Türkiye |
|
Ceyhan Özbeyaz
Türkiye |
| Özet |
| This study aimed to investigate the metabolic effects of propylene glycol (PG) over 60, 90, and 120 days in lambs. Seventy-two weaned male lambs were allocated into three groups: control (Con), PG1.5 (1.5 mL/kg live weight ), and PG3 (3 mL/kg live weight ). Blood samples were collected at the beginning and slaughter days. Biochemical parameters (glucose, triglycerides, ALT, AST, LDH, BUN, and insulin) and gene and protein levels of peroxisome proliferator activated receptor gamma (PPARγ), diacylglycerol o-acyltransferase 1 (DGAT1), carbohydrate responsive element binding protein (ChREBP), and sterol regulatory element binding transcription factor 1c (SREBP-1c) in the liver were determined. Glucose in PG1.5 was increased on Day 60, while significant differences were observed in biochemical parameters except for insulin on the 60, 90, and 120 days. Biochemical parameters such as ALT, AST, LDH, and BUN increased over time, while triglycerides decreased. DGAT1 gene and protein levels were lower, while SREBP-1c and PPARγ were higher in PG groups on Day 60. While SREBP-1c was lower in PG1.5, ChREBP was higher in PG3 on Day 90. PPARγ, DGAT1, and ChREBP were upregulated in PG3 on Day 120. Positive correlations were found between proteins. The long-term use of PG in lambs did not have detrimental effects on metabolism. The study provides valuable insights into the molecular mechanisms underlying the metabolic effects of PG in lambs, shedding light on its potential applications in lamb production. |
| Anahtar Kelimeler |
| gene expression | lamb ration | metabolism | propylene glycol | protein expression |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Animal Science Journal |
| Dergi ISSN | 1344-3941 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2023 |
| Cilt No | 94 |
| Sayı | 1 |
| Sayfalar | 1 / 12 |
| Doi Numarası | 10.1111/asj.13886 |
| Makale Linki | http://dx.doi.org/10.1111/asj.13886 |
| Atıf Sayıları |
