| Yazarlar (8) |
Cengiz Gökbulut
Balıkesir Üniversitesi, Türkiye |
|
Veli Yılgör Çırak
Bursa Uludağ Üniversitesi, Türkiye |
|
Süleyman Aypak
Aydın Adnan Menderes Üniversitesi, Türkiye |
|
Hamdi Avcı
Aydın Adnan Menderes Üniversitesi, Türkiye |
|
Selim Sekkin
Aydın Adnan Menderes Üniversitesi, Türkiye |
|
Hande Sultan Şahiner
Aydın Adnan Menderes Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Buket BOĞA KURU
Kafkas Üniversitesi, Türkiye |
|
Erol Ayaz
Bolu Abant İzzet Baysal Üniversitesi, Türkiye |
| Özet |
| Sheep and goats are sharing different helminth parasites including Haemonchus contortus. Control of these helminths is based mainly on the use of anthelmintics. However, in goats, the application of anthelmintics is often carried out mainly at dosages determined for sheep without knowing the real effects and metabolism features. One of the several anthelmintic classes used against these parasites is (pro) benzimidazoles which are still widely in use in small ruminants in many countries. The objective of this study was to determine (i) the correlation between plasma and tissue or gastrointestinal content dispositions of ricobendazole (RBZ) in goats and (ii) the in vivo exposure of ricobendazole by H. contortus. Ten goats were experimentally infected with 10,000 larvae of H. contortus. Four weeks of post-infection, the animals received RBZ subcutaneously at 5 mg/kg body weight. Two goats were sacrificed per time at 1, 2, 4, 6 and 12 h after drug administration and, blood, bile, urine, liver, lung, muscle and kidney gastrointestinal tissues/fluids were collected. Adult H. contortus were collected from abomasum, and all samples were analysed by HPLC system. Ricobendazole (RBZ) and its sulphone metabolite were extensively excreted by urine and distributed to all tissues and digestive tract, mainly into the abomasum fluid. RBZ concentration in the lung and ABZSO in the kidney were relatively higher than those of other tissues, respectively. The parent drug and its metabolite were recovered in both male and female H. contortus. This study indicates that in goats the plasma concentration profiles of RBZ are strongly correlated with those achieved in different target tissues or fluids, which in turn, reflect the amount of drug taken up by parasites. |
| Anahtar Kelimeler |
| albendazole sulphoxide | benzimidazoles | goat | Haemonchus contortus | ricobendazole |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Veterinary Pharmacology and Therapeutics |
| Dergi ISSN | 0140-7783 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2021 |
| Cilt No | 44 |
| Sayı | 5 |
| Sayfalar | 799 / 807 |
| Doi Numarası | 10.1111/jvp.12974 |
| Makale Linki | http://dx.doi.org/10.1111/jvp.12974 |
| Atıf Sayıları |
