Investigation of in vitro antimicrobial and cytotoxic effects of gold nanoparticles capped with meropenem and imipenem
Yazarlar (5)
Dr. Öğr. Üyesi Nurullah ÇİFTÇİ Kafkas Üniversitesi, Türkiye
İdris Sargın Selçuk Üniversitesi, Türkiye
Prof. Dr. Gülşin Arslan Selçuk Üniversitesi, Türkiye
Prof. Dr. Serdar Karakurt Türkiye
Prof. Dr. Uğur Arslan Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | NANOMEDICINE (Q1) | ||
| Dergi ISSN | 1743-5889 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2023 |
| Cilt / Sayı / Sayfa | 18 / 24 / 1719–1731 | DOI | 10.2217/nnm-2023-0223 |
| Makale Linki | http://dx.doi.org/10.2217/nnm-2023-0223 | ||
| UAK Araştırma Alanları |
Tıbbi Mikrobiyoloji
|
||
| Özet |
| Aim This study aimed to investigate the in vitro antimicrobial effect of gold nanoparticles capped with meropenem and imipenem against various strains and to evaluate the cytotoxic effect of gold nanoparticles on healthy human colon epithelial cells. Materials & methods Gold nanoparticles were synthesized via the Turkevich method and tested for antimicrobial effects using broth microdilution. Cell culture studies were performed using a cytotoxicity assay with alamarBlue™. Results & conclusion Nanoparticles (10–20 nm) with antibiotic coating were more effective against Escherichia coli, Proteus spp. and Serratia marcescens than pure antibiotics. They had a cytotoxic effect on cells at high concentrations but were safe at low concentrations. |
| Anahtar Kelimeler |
| antimicrobial resistance | cell culture | gold nanoparticles | imipenem | meropenem |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Google Scholar | 3 |