| Yazarlar |
İnan Gezgin
Türkiye |
Dr. Öğr. Üyesi Cem ÖZİÇ
Kafkas Üniversitesi, Türkiye |
| Özet |
| AIM: To investigate the expression of the DR4, DR5, OPG, DcR1, and DcR2 in rat brain tissue.MATERIAL and METHODS: Thirty rats were used in this study. The rats were divided into three groups as the control group (n=10),tumor group (n=10), and zincoxide (ZnO) nanoparticles (NP) treatment group (n=10). The reverse transcription polymerase chainreaction (RT-PCR) and Western Blotting methods were used to measure the expression of DR4, DR5, OPG, DcR1, DcR2 and β-actinin the brain tissues of all the three groups.RESULTS: Expression of DR4, DR5, OPG, DcR1, and DcR2 genes were decreased in the tumor group. Overexpression of DR4,DR5, OPG, DcR1, and DcR2 was observed in brain tissues of the ZnO-NP group.CONCLUSION: Increased expression of the DR4, DR5, OPG, DcR1, and DcR2 genes may play an important role in ZnO-NPtreatment of brain tumors. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Turkish Neurosurgery |
| Dergi ISSN | 1019-5149 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2020 |
| Cilt No | 30 |
| Sayı | 3 |
| Sayfalar | 350 / 353 |
| Doi Numarası | 10.5137/1019-5149.JTN.21557-17.4 |
| Makale Linki | http://www.turkishneurosurgery.org.tr/summary_en_doi.php3?doi=10.5137/1019-5149.JTN.21557-17.4 |
| Atıf Sayıları |
