Effects of zinc oxide on mrna expression of genes in brain tissue of rats
Yazarlar (2)
İnan Gezgin
T.C. Sağlık Bakanlığı, Türkiye
T.C. Sağlık Bakanlığı, Türkiye
Dr. Öğr. Üyesi Cem ÖZİÇ Kafkas Üniversitesi, Türkiye
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Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Turkish Neurosurgery (Q4) | ||
| Dergi ISSN | 1019-5149 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2020 |
| Cilt / Sayı / Sayfa | 30 / 3 / 350–353 | DOI | 10.5137/1019-5149.JTN.21557-17.4 |
| Makale Linki | http://www.turkishneurosurgery.org.tr/summary_en_doi.php3?doi=10.5137/1019-5149.JTN.21557-17.4 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| AIM: To investigate the expression of the DR4, DR5, OPG, DcR1, and DcR2 in rat brain tissue.MATERIAL and METHODS: Thirty rats were used in this study. The rats were divided into three groups as the control group (n=10),tumor group (n=10), and zincoxide (ZnO) nanoparticles (NP) treatment group (n=10). The reverse transcription polymerase chainreaction (RT-PCR) and Western Blotting methods were used to measure the expression of DR4, DR5, OPG, DcR1, DcR2 and β-actinin the brain tissues of all the three groups.RESULTS: Expression of DR4, DR5, OPG, DcR1, and DcR2 genes were decreased in the tumor group. Overexpression of DR4,DR5, OPG, DcR1, and DcR2 was observed in brain tissues of the ZnO-NP group.CONCLUSION: Increased expression of the DR4, DR5, OPG, DcR1, and DcR2 genes may play an important role in ZnO-NPtreatment of brain tumors. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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