Effects of zinc oxide on mrna expression of genes in brain tissue of rats
Yazarlar (2)
İnan Gezgin T.C. Sağlık Bakanlığı, Türkiye
Dr. Öğr. Üyesi Cem ÖZİÇ Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Turkish Neurosurgery (Q4) | ||
| Dergi ISSN | 1019-5149 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2020 |
| Cilt / Sayı / Sayfa | 30 / 3 / 350–353 | DOI | 10.5137/1019-5149.JTN.21557-17.4 |
| Makale Linki | http://www.turkishneurosurgery.org.tr/summary_en_doi.php3?doi=10.5137/1019-5149.JTN.21557-17.4 | ||
| Özet |
| AIM: To investigate the expression of the DR4, DR5, OPG, DcR1, and DcR2 in rat brain tissue.MATERIAL and METHODS: Thirty rats were used in this study. The rats were divided into three groups as the control group (n=10),tumor group (n=10), and zincoxide (ZnO) nanoparticles (NP) treatment group (n=10). The reverse transcription polymerase chainreaction (RT-PCR) and Western Blotting methods were used to measure the expression of DR4, DR5, OPG, DcR1, DcR2 and β-actinin the brain tissues of all the three groups.RESULTS: Expression of DR4, DR5, OPG, DcR1, and DcR2 genes were decreased in the tumor group. Overexpression of DR4,DR5, OPG, DcR1, and DcR2 was observed in brain tissues of the ZnO-NP group.CONCLUSION: Increased expression of the DR4, DR5, OPG, DcR1, and DcR2 genes may play an important role in ZnO-NPtreatment of brain tumors. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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