| Yazarlar (10) |
Ebru Gök Oğuz
|
|
Hadim Akoğlu
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Gülay Ulusal Okyay
|
|
Güner Karaveli Gürsoy
|
|
Tolga Yıldırım
Hacettepe Üniversitesi, Türkiye |
|
Özgür Merhametsiz
|
|
Tolga Çimen
|
Prof. Dr. Başol CANBAKAN
Kafkas Üniversitesi, Türkiye |
|
Ekrem Yeter
|
|
Mehmet Deniz Aylı
Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
BackgroundRenalase, with possible monoamine oxidase activity, is implicated in degradation of catecholamines; which suggests novel mechanisms of cardiovascular complications in patients with chronic kidney diseases. Epicardial adipose tissue (EAT) has been found to correlate with cardiovascular diseases (CVD) in dialysis patients. The present study aimed to evaluate the association of serum renalase levels with EAT thickness and other CVD risk factors in peritoneal dialysis (PD) patients.MethodsThe study included 40 PD patients and 40 healthy controls. All subjects underwent blood pressure and anthropometric measurements. Serum renalase was assessed by using a commercially available assay. Transthoracic echocardiography was used to measure EAT thickness and left ventricular mass index (LVMI) in all subjects.ResultsThe median serum renalase level was significantly higher in the PD patients than in the control group [176.5 (100-278.3) vs 122 (53.3-170.0)ng/ml] (p=0.001). Renalase was positively correlated with C-reactive protein (r=0.705, p<0.001) and negatively correlated with RRF (r=-0.511, p=0.021). No correlation was observed between renalase and EAT thickness or LVMI. There was a strong correlation between EAT thickness and LVMI in both the PD patients and the controls (r=0.848, p<0.001 and r=0.640, p<0.001 respectively).ConclusionsThis study indicates that renalase is associated with CRP and residual renal function but not with EAT thickness as CVD risk factors in PD patients. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Nefrologia |
| Dergi ISSN | 0211-6995 Wos Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2017 |
| Cilt No | 37 |
| Sayı | 2 |
| Sayfalar | 189 / 194 |
| Doi Numarası | 10.1016/j.nefro.2016 |
| Makale Linki | https://www.ncbi.nlm.nih.gov/pubmed/28160962 |
| Atıf Sayıları |
