| Yazarlar (4) |
Doç. Dr. Erdem TOKTAY
Kafkas Üniversitesi, Türkiye |
Jale Selli
Alanya Alaaddin Keykubat Üniversitesi, Türkiye |
|
Muhammet Ali Gürbüz
Atatürk Üniversitesi, Türkiye |
|
Raziye Alaca
|
| Özet |
| The aim of this study was to investigate the effect of Astaxanthin (ASX) on ovaries in letrozole-induced polycystic ovary syndrome (PCOS) model in female rats by histopathological, immunohistochemical and biochemical techniques. Seventy two Sprague-Dawley female rats with an average weight of 200-250 gr and 10-12 weeks old were randomly divided into 9 groups. PCOS model was applied to all groups except healthy group. In the study, low (10 mg / kg) moderate (20 mg / kg) and high (40 mg / kg) doses of ASX were given to the experimental animals in the PCOS-induced groups for 7 days. At the end of the experiment, ovarian tissues were evaluated histopathologically, immunohistochemically, and biochemically. When the histopathological findings were examined, many cystic follicles, apoptotic and necrotic cells were found in the follicles in the PCOS group. In addition, significant decrease in apoptotic and necrotic cells were observed in PCOS+MET+ASX and PCOS+ASX groups. In immunohistochemical staining findings, while TNF-α NF-κB and IL-6 expression levels showed significant increase in PCOS group, these expression levels were decreased in PCOS+MET+ASX and PCOS+ASX groups. In the biochemical evaluations, while MDA were increased, SOD were decreased in the PCOS group. MDA level were decreased while SOD levels were increased in the PCOS+MET+ASX and PCOS+ASX groups. In addition to the formation of insulin resistance in the tissue, severe oxidative stress damage occurs in ovarian tissue during PCOS. Metformin improved PCOS by correcting insulin resistance. In this period, the administration of ASX with Metformin protected the ovary from oxidative stress damage. |
| Anahtar Kelimeler |
| Astaxanthin | Metformin | Ovary | Oxidative stress | Polycystic ovary syndrome |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Iranian Journal of Basic Medical Sciences |
| Dergi ISSN | 2008-3874 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2023 |
| Cilt No | 26 |
| Sayı | 10 |
| Sayfalar | 1155 / 1161 |
| Doi Numarası | 10.22038/IJBMS.2023.69984.15223 |
| Makale Linki | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510480/ |
| Atıf Sayıları |
