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Clinical and immunohistochemical evaluation of penile tumors in bulls    
Yazarlar
Doç. Dr. Uğur AYDIN Doç. Dr. Uğur AYDIN
Türkiye
Doç. Dr. Emin KARAKURT Doç. Dr. Emin KARAKURT
Türkiye
Prof. Dr. Serpil DAĞ Prof. Dr. Serpil DAĞ
Türkiye
Prof. Dr. Enver BEYTUT Prof. Dr. Enver BEYTUT
Türkiye
Prof. Dr. İsa ÖZAYDIN Prof. Dr. İsa ÖZAYDIN
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hilmi NUHOĞLU Dr. Öğr. Üyesi Hilmi NUHOĞLU
Türkiye
Uğur Yıldız
Türkiye
Emre Kurtbaş
Özet
Fibropapilloma is the most common neoplasic formation associated with bovine papillomavirus type I. It occurs inside the penis of bulls and causes clinically adverse effects, such as phimosis, paraphimosis, urethral stricture, and urinary retention. This study aimed to conduct a clinical and immunohistochemical evaluation of penile tumors, which are associated with adverse outcomes with regard to breeding value and yield in bulls.A total of 40 bulls of different breeds aged between 10 months to 3 years were included in the study. Tumor tissue samples collected postoperatively were fixed in 10% buffered formaldehyde solution. The avidin–biotin–peroxidase method was used for immunohistochemical staining. Three separate areas were examined under 40X objective lens for each fibropapilloma tissue. The immunoreactivity was classified as none (-), mild (+), moderate (++), and severe (+++). Fibropapillomas ranged from 2 to 10 cm in diameter. Thirty-two papillomas were pedunculated and eight were sessile and attached to the body; 30 were solitary and 10 were multiple. There were 13 relapsed cases and 27 non-relapsed cases. Immunohistochemical examination revealed a statistically significant difference in the binary comparisons of proliferating cell nuclear antigen (PCNA) and hypoxanthine-guanine phosphoribosyltransferase (HPRT) based on positive cell scoring between the relapsed and non-relapsed cases. In conclusion, cancer markers such as PCNA and HPRT can be used to evaluate the prognosis and malignancy of penile tumors that cause significant economic losses.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale
Dergi Adı Journal of Advances in VetBio Science and Techniques
Dergi ISSN 2548-1150
Dergi Tarandığı Indeksler TR DİZİN
Makale Dili Türkçe
Basım Tarihi 08-2022
Cilt No 7
Doi Numarası 10.31797/vetbio.1086702
Makale Linki http://dx.doi.org/10.31797/vetbio.1086702
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
TRDizin 1
Clinical and immunohistochemical evaluation of penile tumors in bulls

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