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Two flavonoids, baicalein and naringin, are effective as anti-inflammatory and anti-oxidant agents in a rat model of polymicrobial sepsis     
Yazarlar
Doç. Dr. Pınar BAYRAM
Kafkas Üniversitesi, Türkiye
Prof. Dr. Selina AKSAK KARAMEŞE
Kafkas Üniversitesi, Türkiye
Arş. Gör. Bengül ÖZDEMİR SARIKAYA
Türkiye
Çağatay Salum
Kastamonu Üniversitesi, Türkiye
Hüseyin Serkan Erol
Kastamonu Üniversitesi, Türkiye
Doç. Dr. Murat KARAMEŞE
Türkiye
Özet
In this study, our aim was to investigate the possible protective and therapeutic effects of these two flavonoids, baicalein, and naringin, in 50 and 100 mg/kg doses applied both before and after cecal ligation and puncture (CLP) procedures in a polymicrobial sepsis rat model, and evaluate the possible contribution of oxidative and inflammatory markers by immunological, biochemical, molecular, and histopathological methods.
Anahtar Kelimeler
Sepsis,flavonoids,baicalein,naringin,inflammation,oxidative stress,CLP,TNF-alpha,IL-6
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Immunopharmacology and Immunotoxicology
Dergi ISSN 0892-3973
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q2
Makale Dili Türkçe
Basım Tarihi 04-2023
Cilt No 45
Sayı 5
Sayfalar 597 / 606
Doi Numarası 10.1080/08923973.2023.2197143
Makale Linki http://dx.doi.org/10.1080/08923973.2023.2197143