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Assessment of the levels of some prognostic biomolecules (galectins, ACE2, SCUBE1/2/3) in COVID-19 patients     
Yazarlar
Doç. Dr. Murat KARAMEŞE
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Abdullah GÜMÜŞ
Kafkas Üniversitesi, Türkiye
Doç. Dr. Eray ATALAY
Kafkas Üniversitesi, Türkiye
Emin Ediz Tütüncü
Sağlık Bilimleri Üniversitesi, Türkiye
Özet
Our aim was to investigate the differences between healthy people and COVID-19 patients in terms of some immunological biomolecules, especially including those related to the inflammation process. A total of 180 participants (90 healthy controls and 90 COVID-19 patients) were included. The expression levels of eight different inflammation-related biomolecules were measured by the ELISA technique. The mean levels of ACE2, ANG1-7, GAL3, GAL9, SCUBE1, SCUBE2 and SCUBE3 were elevated in COVID-19 patients when compared with healthy controls, while the mean level of GAL2 was lower in COVID-19 patients than controls. To understand the cytokine storm mechanism and related parameters, more detailed studies should be performed investigating more related biomolecules and related signaling pathways.
Anahtar Kelimeler
ACE2,COVID-19,galectins,inflammation,SARS-CoV-2,SCUBE
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Future Medicine Ltd
Dergi ISSN 1746-0913
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q3
Makale Dili Türkçe
Basım Tarihi 11-2023
Cilt No 18
Sayı 18
Sayfalar 1329 / 1337
Doi Numarası 10.2217/fmb-2023-0099
Makale Linki http://dx.doi.org/10.2217/fmb-2023-0099