An investigation of bovine papillomaviruses from ocular squamous cell carcinomas in cattle
Yazarlar (12)
Doç. Dr. Emin KARAKURT
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nüvit COŞKUN
Kafkas Üniversitesi, Türkiye
U. Aydın
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
E. Beytut
S. Dag
V. S. Ataseven
Mustafa Kemal Üniversitesi, Türkiye
V. Yılmaz
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
F. Dogan
Mustafa Kemal Üniversitesi, Türkiye
H. Nuhoglu
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
C. S. Ermutlu
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Prof. Dr. Mushap KURU
Kafkas Üniversitesi, Türkiye
A. Yıldız
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Iranian Journal of Veterinary Research (Q3) | ||
| Dergi ISSN | 1728-1997 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2023 |
| Cilt / Sayı / Sayfa | 24 / 1 / 51–57 | DOI | 10.22099/ijvr.2022.43152.6282 |
| Makale Linki | https://ijvr.shirazu.ac.ir/article_7005.html | ||
| Özet |
| Background: Ocular squamous cell carcinomas (OSCCs) in cattle has been studied for many years, but no definite etiology has been established. Squamous cell carcinomas (SCCs) may occur in different body parts of cattle. Depending on the location, it can cause an economic loss of varying degrees. Aims: The aim of this study was to investigate the causes of OSCCs in the eye region of cattle. Methods: Sixty tumoral masses taken form 60 cattle with proliferation in the eye region that were collected between the years 2012-2022 were used. These cases were admitted to our department for routine diagnosis. The tissues were diagnosed as OSCC using histopathological methods. The presence of bovine papillomavirus (BPV), one of the causative factors, was investigated using immunohistochemical and polymerase chain reaction (PCR). Results: Macroscopically masses were nodular or cauliflower-like and fragile and had hemorrhagic surfaces. Considering the keratin pearls, tumoral islands, and squamous differentiation, 20 out of 60 cases were classified as well, 20 as moderately, and 20 as poorly-differentiated OSCCs. 47 of the 60 cases were BPV positive using immunohistochemical methods. However, BPV nucleic acid was detected in only two cases with PCR. Only one of the cases could be sequenced. After phylogenetic analysis, virus strain was identified as BPV-1. Conclusion: Our results indicated that papillomaviruses can contribute to the development of OSCCs, in both precursor lesions and also advanced stage OSCCs. We found that BPV-1 has a possible causative role; however, more studies are needed to investigate the role of other viral agents and their interaction with secondary factors. |
| Anahtar Kelimeler |
| Bovine papillomavirus | Immunohistochemistry | Ocular squamous cell carcinoma | PCR |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 5 |
| Google Scholar | 10 |