The relationship between hyperpolypharmacy and one-year outcomes in patients with critical limb ischemia undergoing below-knee endovascular therapy
Yazarlar (10)
Mehmet Altunova
University Of Health Sciences, Türkiye
Recep Gülmez
University Of Health Sciences, Türkiye
Dr. Öğr. Üyesi Muammer KARAKAYALI
Kafkas Üniversitesi, Türkiye
İsmail Gürbak
University Of Health Sciences, Türkiye
Ömer Taşbulak
University Of Health Sciences, Türkiye
Gökhan Demirci
University Of Health Sciences, Türkiye
Arda Güler
University Of Health Sciences, Türkiye
Ali Evsen
Dicle University, Faculty Of Medicine, Türkiye
Ümit Bulut
University Of Health Sciences, Türkiye
Mehmet Ertürk
University Of Health Sciences, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Vascular | ||
| Dergi ISSN | 1708-5381 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2024 |
| Cilt / Sayı / Sayfa | 32 / 2 / 320–329 | DOI | 10.1177/17085381231193496 |
| Makale Linki | http://dx.doi.org/10.1177/17085381231193496 | ||
| Özet |
| Background: Critical limb ischemia (CLI) patients take too many medications because they are elderly and frail patients with multiple comorbidities. Polypharmacy is associated with frailty, although its prognostic significance in CLI patients is unknown. In this study, we aimed to determine the prevalence of hyperpolypharmacy among adults with CLI and its effect on 1-year amputation and mortality. Methods: A total of 200 patients with CLI who underwent endovascular therapy (EVT) for below-knee (CTC) lesions were included in this study. Hyperpolypharmacy was defined as using ≥10 drugs. Patients were divided into two groups according to the presence of hyperpolypharmacy Results: We detected hyperpolypharmacy in 66 patients. The incidence of 1-year amputation [24 (36.4) versus 12 (9), p<.001] and mortality [28 (42.4) versus 12 (9), p<.001] were higher in patients with hyperpolypharmacy. Univariate and multivariate cox regression analyses were used to determine the independent predictors of amputation and mortality. In the receiver operating characteristic curve analysis, the cut-off value was defined as 10 or more drug use was able to detect the presence of 1-year mortality with 67.5% sensitivity and 79.4% specificity. The Kaplan–Meier method showed a significant difference (rank p <.001 between log groups), and hyperpolypharmacy was associated with 1-year amputation and mortality. Conclusion: Hyperpolypharmacy was significantly associated with 1-year mortality and major amputation in CLI patients. Hyperpolypharmacy can be a valuable aid in patient risk assessment in the CLI. |
| Anahtar Kelimeler |
| 1-year mortality | critical limb ischemia | endovascular therapy | Hyperpolypharmacy | major amputation |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 3 |
| SCOPUS | 3 |
| Google Scholar | 4 |