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How Did the Updated 2019 European Society of Cardiology/European Atherosclerosis Society Risk Categorization for Patients with Diabetes Affect the Risk Perception and Lipid Goals? A Simulated Analysis of Real-life Data from EPHESUS Study   
Yazarlar
Özcan Başaran
Muğla Sıtkı Koçman Üniversitesi, Türkiye
Volkan Doğan
Muğla Sıtkı Koçman Üniversitesi, Türkiye
Kadir Uğur Mert
Eskişehir Osmangazi Üniversitesi, Türkiye
Bülent Özlek
Muğla Sıtkı Koçman Üniversitesi, Türkiye
Eda Özlek
Türkiye
Oğuzhan Çelik
Muğla Sıtkı Koçman Üniversitesi, Türkiye
Cem Çil
Türkiye
İbrahim Halil Özdemir
Türkiye
Prof. Dr. İbrahim RENCÜZOĞULLARI Prof. Dr. İbrahim RENCÜZOĞULLARI
Kafkas Üniversitesi, Türkiye
Fatma Özpamuk Karadeniz
Karamanoğlu Mehmetbey Üniversitesi, Türkiye
Mehmet Tekinalp
Türkiye
Lütfü Aşkın
Gaziantep İslam Bilim ve Teknoloji Üniversitesi, Türkiye
Selami Demirelli
Sağlık Bilimleri Üniversitesi, Türkiye
Erkan Gencer
Lütfü Bekar
Hitit Üniversitesi, Türkiye
Müjdat Aktaş
Türkiye
Mübariz Murat Resulzade
Macit Kalçık
Hitit Üniversitesi, Türkiye
Gökhan Aksan
Türkiye
Göksel Çinier
Sağlık Bilimleri Üniversitesi, Türkiye
Kadriye Halli Akay
Nihat Pekel
Türkiye
Gurbet Özge Mert
Eskişehir Osmangazi Üniversitesi, Türkiye
Utku Şenol
Türkiye
Vahit Demir
Türkiye
Sinan İnci
Türkiye
Emir Derviş
Türkiye
Murat Biteker
Türkiye
Latife Meral Kayıkçıoğlu
Ege Üniversitesi, Türkiye
Özet
Background: The recent 2019 European Society of Cardiology/European Atherosclerosis Society practice guidelines introduced a new risk categorization for patients with diabetes. We aimed to compare the implications of the 2016 and 2019 European Society of Cardiology/European Atherosclerosis Society guidelines with regard to the lipid-lowering treatment use, low-density lipoprotein cholesterol goal attainment rates, and the estimated proportion of patients who would be at goal in an ideal setting. Methods: Patients with diabetes were classified into 4 risk categories according to 2019 European Society of Cardiology/European Atherosclerosis Society dyslipidemia guidelines from the database of EPHESUS (cross-sectional, observational, countrywide registry of cardiology outpatient clinics) study. The use of lipid-lowering treatment and low-density lipoprotein cholesterol goal attainment rates were then compared according to previous and new guidelines. Results: This analysis included a total of 873 diabetic adults. Half of the study population (53.8%) were on lipid-lowering treatment and almost one-fifth (19.1%) were on highintensity statins. While low-density lipoprotein cholesterol goal was achieved in 19.5% and 7.5% of patients, 87.4% and 69.6% would be on target if their lipid-lowering treatment was intensified according to 2016 and 2019 European Society of Cardiology/European Atherosclerosis Society lipid guidelines, respectively. The new target <55 mg/dL could only be achieved in 2.2% and 8.1% of very high-risk primary prevention and secondary prevention patients, respectively. Conclusion: The control of dyslipidemia was extremely poor among patients with diabetes. The use of lipid-lowering treatment was not at the desired level, and high-intensity lipid-lowering treatment use was even lower. Our simulation model showed that the highdose statin plus ezetimibe therapy would improve goal attainment; however, it would not be possible to get goals with this treatment in more than one-third of the patients.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Kare Publishing
Dergi ISSN 2149-2263
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q3
Makale Dili İngilizce
Basım Tarihi 02-2023
Cilt No 27
Sayı 2
Sayfalar 78 / 87
Doi Numarası 10.14744/AnatolJCardiol.2022.2012
Makale Linki http://dx.doi.org/10.14744/anatoljcardiol.2022.2012