| Yazarlar |
Doç. Dr. Emin KARAKURT
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Nüvit COŞKUN
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Uğur AYDIN
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Serpil DAĞ
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Enver BEYTUT
Kafkas Üniversitesi, Türkiye |
Veysel Soydal Ataseven
Hatay Mustafa Kemal Üniversitesi, Türkiye |
Prof. Dr. Volkan YILMAZ
Kafkas Üniversitesi, Türkiye |
|
Fırat Doğan
Hatay Mustafa Kemal Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Hilmi NUHOĞLU
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Celal Şahin ERMUTLU
Kafkas Üniversitesi, Türkiye |
Arş. Gör. Ayfer YILDIZ UYSAL
Kafkas Üniversitesi, Türkiye |
| Özet |
| This study was aimed at the evaluation of cell proliferation, p53 level and apoptotic index by immunohistochemical methods in canine oral papillomatosis. The study material comprised of tumor tissue samples taken from six dogs being admitted to the Pathology Department of Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye. Choice of immunohistochemical staining was avidin-biotin peroxidase method. Cases of canine oral papillomatosis, determined to have been caused by canine papillomavirus-1, were found to have a rather high cell proliferation index. Furthermore, all cases were immunohisto-chemically demonstrated to carry a mutant p53 gene. Despite the mutation of p53 gene, the shift in the Bax/Bcl-2 ratio of dogs diagnosed with tumor was in favor of the pro-apoptotic Bax gene. The apoptotic mechanism was determined to occur through both the caspase-dependent and caspase-independent pathways. While the lesions occupied the entire oral cavity in some cases, histopathologically, malignant transformation was not detected in any of the six cases. |
| Anahtar Kelimeler |
| Apoptosis | Canine | p53 | Papillomatosis | Proliferation |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Veterinary Research Forum |
| Dergi ISSN | 2008-8140 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2024 |
| Cilt No | 15 |
| Sayı | 2 |
| Sayfalar | 75 / 82 |
| Doi Numarası | 10.30466/vrf.2023.1996086.3818 |
| Makale Linki | https://vrf.iranjournals.ir/article_709148.html |
| Atıf Sayıları |
