Sulfonamide derivatives with benzothiazole scaffold: Synthesis and carbonic anhydrase I–II inhibition properties
Yazarlar (7)
Cansu Öztürk
Doç. Dr. Erbay KALAY Kafkas Üniversitesi, Türkiye
Serpil Gerni
Dr. Öğr. Üyesi Neslihan Balcı Gümüşhane Üniversitesi, Türkiye
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Osman Nuri Aslan Atatürk Üniversitesi, Türkiye
Emrah Polat
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (Q2) | ||
| Dergi ISSN | 0885-4513 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2024 |
| Cilt / Sayı / Sayfa | 71 / 1 / 223–231 | DOI | 10.1002/bab.2534 |
| Makale Linki | https://iubmb.onlinelibrary.wiley.com/doi/epdf/10.1002/bab.2534 | ||
| UAK Araştırma Alanları |
Organik Kimya
Biyokimya
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| Özet |
| The secondary sulfonamide derivatives containing benzothiazole scaffold (1-10) were synthesized to determine their inhibition properties on two physiologically essential human carbonic anhydrases isoforms (hCAs, EC, 4.2.1.1), hCA I, and hCA II. The inhibitory effects of the compounds on hCA I and hCA II isoenzymes were investigated by comparing their IC and K values. The K values of compounds (1-10) against hCA I and hCA II are in the range of 0.052 ± 0.022-0.971 ± 0.280 and 0.025 ± 0.010-0.682 ± 0.335, respectively. Some of these inhibited the enzyme more effectively than the standard drug, acetazolamide. In particular, compounds 5 and 4 were found to be most effective on hCA I and hCA II. |
| Anahtar Kelimeler |
| benzothiazole moiety | human carbonic anhydrase I | human carbonic anhydrase II | inhibition | secondary sulfonamide derivatives |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 10 |