Cell proliferation and apoptosis in canine oral papillomatosis
Yazarlar (11)
Doç. Dr. Emin KARAKURT
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nüvit COŞKUN
Kafkas Üniversitesi, Türkiye
Doç. Dr. Uğur AYDIN
Kafkas Üniversitesi, Türkiye
Prof. Dr. Serpil DAĞ
Kafkas Üniversitesi, Türkiye
Prof. Dr. Enver BEYTUT
Kafkas Üniversitesi, Türkiye
Hatay Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Volkan YILMAZ
Kafkas Üniversitesi, Türkiye
Hatay Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hilmi NUHOĞLU
Kafkas Üniversitesi, Türkiye
Prof. Dr. Celal Şahin ERMUTLU
Kafkas Üniversitesi, Türkiye
Arş. Gör. Ayfer YILDIZ UYSAL
Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Veterinary Research Forum |
| Dergi ISSN | 2008-8140 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2024 |
| Cilt No | 15 |
| Sayı | 2 |
| Sayfalar | 75 / 82 |
| DOI Numarası | 10.30466/vrf.2023.1996086.3818 |
| Özet |
| This study was aimed at the evaluation of cell proliferation, level and apoptotic index by immunohistochemical methods in canine oral papillomatosis. The study material comprised of tumor tissue samples taken from six dogs being admitted to the Pathology Department of Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye. Choice of immunohistochemical staining was avidin-biotin peroxidase method. Cases of canine oral papillomatosis, determined to have been caused by canine papillomavirus-1, were found to have a rather high cell proliferation index. Furthermore, all cases were immunohisto-chemically demonstrated to carry a mutant gene. Despite the mutation of gene, the shift in the / ratio of dogs diagnosed with tumor was in favor of the pro-apoptotic gene. The apoptotic mechanism was determined to occur through both the caspase-dependent and caspase-independent pathways. While the lesions occupied the entire oral cavity in some cases, histopathologically, malignant transformation was not detected in any of the six cases. |
| Anahtar Kelimeler |
| Apoptosis | Papillomatosis | Proliferation | Canine | p53 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |