| Yazarlar |
Emin KARAKURT
Kafkas Üniversitesi, Türkiye |
Uğur AYDIN
Kafkas Üniversitesi, Türkiye |
Enver BEYTUT
Kafkas Üniversitesi, Türkiye |
Serpil DAĞ
Kafkas Üniversitesi, Türkiye |
Özgür AKSOY
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Hilmi NUHOĞLU
Kafkas Üniversitesi, Türkiye |
Uğur Yıldız
Türkiye |
Arş. Gör. Ayfer YILDIZ UYSAL
Kafkas Üniversitesi, Türkiye |
| Özet |
| Oxidative stress is strongly linked to carcinogenesis, especially head, neck and oral SCCs in humans. In this study, we aimed to evaluate the role of oxidative and nitrosative stress in Bovine ocular squamous cell carcinomas (BOSCCs) using immunohistochemical markers such as Nitrotyrosine (NT), Malondialdehyde (MDA) and 8-hydroxy-2’-deoxyguanosine (8-OHdG). Tissues were collected from 24 cattle brought to the Pathology Department for routine diagnosis. Tumour samples were fixed in 10% neutral buffered formalin, processed routinely, and embedded in paraffin wax. Tissue sections were cut into 5 μm thickness and stained with Hematoxylin-Eosin to detect histopathological changes. The sections were examined under a light microscope and photographed. The avidin-biotin-peroxidase method was used as immunohistochemical staining. It was observed that the cauliflower-like tumoral masses were mostly located on the upper and lower eyelids, the third eyelid, cornea, limbus, or covering the entire eyeball. NT, MDA and 8-OHdG expressions were statistically increased in poorly-differentiated (PD) cases compared to well-differentiated (WD) and moderately-differentiated (MD) cases. On the basis of the results of the increase in these markers, we concluded that nitrosative and oxidative stress may have an important role in the carcinogenesis of BOSCCs. |
| Anahtar Kelimeler |
| bovine | nitrosative stress | oxidative stress | squamous cell carcinoma |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | VETERINARSKI ARHIV |
| Dergi ISSN | 0372-5480 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2024 |
| Cilt No | 94 |
| Sayı | 2 |
| Sayfalar | 109 / 118 |
| Doi Numarası | 10.24099/vet.arhiv.2129 |
| Makale Linki | http://vetarhiv.vef.unizg.hr/papers/2024-94-2-2.pdf?ci=udmpuuefggeunqjsmgftbetgr |
| Atıf Sayıları |
