Assessing mental health in children and adolescent with MTHFR polymorphisms: psychiatric disorders, executive functioning, and symptom profile in a Turkish clinical sample
     
Yazarlar (5)
Onur Tuğçe Poyraz Fındık Marmara Üniversitesi Tip Fakültesi, Türkiye
Duygu Murat Specialty Healthcare, Türkiye
Funda Gümüştaş Marmara Üniversitesi Tip Fakültesi, Türkiye
Ayşe Rodopman Arman Marmara Üniversitesi Tip Fakültesi, Türkiye
Prof. Dr. Işıl ÖZER Ondokuz Mayis University, Medical School, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Children S Health Care (Q4)
Dergi ISSN 0273-9615 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 01-2021
Cilt / Sayı / Sayfa 50 / 2 / 220–237 DOI 10.1080/02739615.2021.1871616
Makale Linki http://dx.doi.org/10.1080/02739615.2021.1871616
Özet
This study investigated behavioral phenotype, executive functions profile, and the existence of comorbid psychiatric disorders in children and adolescents with methylenetetrahydrofolate reductase (MTHFR) polymorphisms admitted to pediatric metabolism outpatient clinic. Internalizing problems, especially somatic complaints were common in patients with MTHFR. More than half of the cases had emotional control and initiating problems as executive function deficits. Attention-deficit/hyperactivity disorder was the most common psychiatric diagnosis, followed by anxiety disorder. Current findings emphasize that health care providers should be aware of the mental health needs of cases with MTHFR polymorphism in order to make plans of integrative physical and mental health care.
Anahtar Kelimeler
attention-deficit hyperactivity disorder | executive function | genetics | mental health | Methylenetetrahydrofolate reductase (NADPH2)