Yazarlar |
Zahraa S. Al-Garawi
Mustansiriyah University, Iraq |
Ahmad H.Ismail Al-Qaisi
Mustansiriyah University, Iraq |
Kawthar Amer Al-Shamari
Mustansiriyah University, Iraq |
Doç. Dr. Füreya Elif ÖZTÜRKKAN
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Hacali NECEFOĞLU
Kafkas Üniversitesi, Türkiye |
Özet |
Green synthesis of metal oxides as a treatment for bone diseases is still exploring. Herein, MgO and Fe2O3 NPs were prepared from the extract of Hibiscus sabdariffa L. to study their effect on vit D3, Ca+2, and alkaline phosphatase enzyme ALP associated with osteoporosis. Computational chemistry was utilized to gain insight into the possible interactions. These oxides were characterized by X-ray diffraction, SEM, FTIR, and AFM. Results revealed that green synthesis of MgO and Fe2O3 NPs was successful with abundant. MgO NPs were in vitro applied on osteoporosis patients (n = 35) and showed a significant elevation of vit D3 and Ca+2 (0.0001 > p < 0.001) levels, compared to healthy volunteers (n = 25). Thus, Hibiscus sabdariffa L. is a good candidate to prepare MgO NPs, with a promising enhancing effect on vit D3 and Ca+2 in osteoporosis. In addition, interactions of Fe2O3 and MgO NPs with ALP were determined by molecular docking study. Graphical abstract: (Figure presented.) |
Anahtar Kelimeler |
Fe2O3 NPs | Molecular docking | Green synthesis | MgO NPs | Osteoporosis | Hibiscus sabdariffa L. |
Makale Türü | Özgün Makale |
Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
Dergi Adı | BIOPROCESS AND BIOSYSTEMS ENGINEERING |
Dergi ISSN | 1615-7591 |
Dergi Grubu | Q2 |
Makale Dili | İngilizce |
Basım Tarihi | 05-2024 |
Cilt No | 47 |
Sayı | 5 |
Sayfalar | 753 / 766 |
Doi Numarası | 10.1007/s00449-024-03012-5 |