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The utility of Hibiscus sabdariffa L. to prepare metal oxides NPs for clinical application on osteoporosis supported by theoretical study    
Yazarlar
Zahraa S. Al-Garawi
Mustansiriyah University, Iraq
Ahmad H.Ismail Al-Qaisi
Mustansiriyah University, Iraq
Kawthar Amer Al-Shamari
Mustansiriyah University, Iraq
Doç. Dr. Füreya Elif ÖZTÜRKKAN Doç. Dr. Füreya Elif ÖZTÜRKKAN
Kafkas Üniversitesi, Türkiye
Prof. Dr. Hacali NECEFOĞLU Prof. Dr. Hacali NECEFOĞLU
Kafkas Üniversitesi, Türkiye
Özet
Green synthesis of metal oxides as a treatment for bone diseases is still exploring. Herein, MgO and Fe2O3 NPs were prepared from the extract of Hibiscus sabdariffa L. to study their effect on vit D3, Ca+2, and alkaline phosphatase enzyme ALP associated with osteoporosis. Computational chemistry was utilized to gain insight into the possible interactions. These oxides were characterized by X-ray diffraction, SEM, FTIR, and AFM. Results revealed that green synthesis of MgO and Fe2O3 NPs was successful with abundant. MgO NPs were in vitro applied on osteoporosis patients (n = 35) and showed a significant elevation of vit D3 and Ca+2 (0.0001 > p < 0.001) levels, compared to healthy volunteers (n = 25). Thus, Hibiscus sabdariffa L. is a good candidate to prepare MgO NPs, with a promising enhancing effect on vit D3 and Ca+2 in osteoporosis. In addition, interactions of Fe2O3 and MgO NPs with ALP were determined by molecular docking study. Graphical abstract: (Figure presented.)
Anahtar Kelimeler
Fe2O3 NPs | Molecular docking | Green synthesis | MgO NPs | Osteoporosis | Hibiscus sabdariffa L.
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı BIOPROCESS AND BIOSYSTEMS ENGINEERING
Dergi ISSN 1615-7591
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 05-2024
Cilt No 47
Sayı 5
Sayfalar 753 / 766
Doi Numarası 10.1007/s00449-024-03012-5