Endothelin-1, pentraxin-3, acute phase proteins and oxidative stress before and after treatment in neonatal calves with sepsis caused by Escherichia coli K99
Yazarlar (1)
Prof. Dr. Mushap KURU Kafkas Üniversitesi, Türkiye
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) (Uluslararası alan indekslerindeki dergilerde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale) | ||
| Dergi Adı | ResearchSquare | ||
| Dergi Tarandığı Indeksler | |||
| Makale Dili | İngilizce | Basım Tarihi | 03-2022 |
| Cilt / Sayı / Sayfa | 0 / 0 / – | DOI | 10.21203/rs.3.rs-1418185 |
| Makale Linki | http://www.scopus.com/inward/record.url?eid=2-s2.0-85134105479&partnerID=MN8TOARS | ||
| Özet |
| This study aimed to detect changes in acute-phase proteins endothelin-1 (ET-1), pentraxin-3 (P-3), ceruloplasmin (Cp), haptoglobin (Hp), and albumin, in calves with diarrhea caused by Escherichia coli K99 neonatal sepsis before and after treatment. Diagnostic and prognostic clinical, biochemical, and hematological parameters were evaluated. A total of 30 calves, divided into a sepsis group and a healthy control group, were assessed. The sepsis group was composed of 20 newborn calves (0–10 days old) which met neonatal sepsis criteria, did not receive any treatment, and were referred to the clinics of the Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, within 24 hours after the detection of clinical ndings. The control group consisted of 10 healthy calves (0–10 days old) for comparison. Clinical examinations (respiratory rate, rectal temperature, heart rate, capillary re ll time, sucking re ex) were performed before (0th h) and after (7th d) treatment. Blood samples were drawn via the jugular vein from sick calves before and after treatment and once from control animals. The P-3, ET-1, Cp, Hp, and malondialdehyde (MDA) concentrations in the sepsis group before treatment were statistically higher than post-treatment and control group values (P< 0.001); while the glutathione (GSH) concentration was statistically lower (P= 0.002). In conclusion, the high pre-treatment concentrations of P-3, ET-1, Cp, Hp, and MDA in the sepsis group were of diagnostic importance. The approximation of these parameters after treatment to the mean values of the control group was also of prognostic value. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |