| Yazarlar |
| Özet |
| This study aimed to detect changes in acute-phase proteins endothelin-1 (ET-1), pentraxin-3 (P-3), ceruloplasmin (Cp), haptoglobin (Hp), and albumin, in calves with diarrhea caused by Escherichia coli K99 neonatal sepsis before and after treatment. Diagnostic and prognostic clinical, biochemical, and hematological parameters were evaluated. A total of 30 calves, divided into a sepsis group and a healthy control group, were assessed. The sepsis group was composed of 20 newborn calves (0--10 days old) which met neonatal sepsis criteria, did not receive any treatment, and were referred to the clinics of the Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, within 24 hours after the detection of clinical findings. The control group consisted of 10 healthy calves (0--10 days old) for comparison. Clinical examinations (respiratory rate, rectal temperature, heart rate, capillary refill time, sucking reflex) were performed before (0th h) and after (7th d) treatment. Blood samples were drawn via the jugular vein from sick calves before and after treatment and once from control animals. The P-3, ET-1, Cp, Hp, and malondialdehyde (MDA) concentrations in the sepsis group before treatment were statistically higher than post-treatment and control group values (P< 0.001); while the glutathione (GSH) concentration was statistically lower (P= 0.002). In conclusion, the high pre-treatment concentrations of P-3, ET-1, Cp, Hp, and MDA in the sepsis group were of diagnostic importance. The approximation of these parameters after treatment to the mean values of the control group was also of prognostic value. |
| Anahtar Kelimeler |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | ResearchSquare |
| Dergi Tarandığı Indeksler | |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2022 |
| Doi Numarası | 10.21203/rs.3.rs-1418185 |
| Makale Linki | http://www.scopus.com/inward/record.url?eid=2-s2.0-85134105479&partnerID=MN8TOARS |
| Atıf Sayıları |
