| Yazarlar |
Dr. Öğr. Üyesi İnanç ARTAÇ
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Metin ÖĞÜN
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Timor OMAR
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Muammer KARAKAYALI
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Doğan İLİŞ
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Ayça ARSLAN
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Yavuz KARABAĞ
Kafkas Üniversitesi, Türkiye |
Prof. Dr. İbrahim RENCÜZOĞULLARI
Kafkas Üniversitesi, Türkiye |
| Özet |
| Objective: Atrial High Rate Episodes (AHRE) are subclinical atrial tachyarrhythmias detectable by cardiac implantable electronic devices (CIEDs). AHREs have been associated with an increased risk of developing atrial fibrillation (AF), thromboembolism, cardiovascular and cerebrovascular events, and mortality. Although recent studies have assessed the value of oxidative stress markers in patients with AF, the relationships between AHRE and oxidative stress markers, including nitric oxide, has not yet been elucidated. This study aims to investigate the relationship between these markers and AHRE. Method: This prospective, cross-sectional study comprised 180 patients with CIEDs. The study population was divided into two groups based on the presence (n = 78) and absense (n = 102) of AHRE to analyze its association with biomarkers. Results: The AHRE (+) group was significantly older, had a higher prevalence of hypertension, higher NT-proBNP (508.8 ± 249 pg/mL vs. 415.3 ± 292.1; P = 0.037), malondialdehyde (MDA) levels (20.9 ± 4.1 μmol/L vs. 19.1 ± 3.1 μmol/L; P = 0.006), and inducible nitric oxide synthase (iNOS) activity (1,935.9 ± 326.1 pg/mL vs. 1,677.4 ± 363.2 pg/mL; P < 0.001). Logistic regression analysis identified age, hypertension, MDA (odds ratio [OR]: 1.131, 95%CI: 1.009 - 1.268, P = 0.035), iNOS activity (OR = 1.002, 95% CI = 1.001 - 1.003, P < 0.001), and endothelial nitric oxide synthase (eNOS) activity (OR = 0.990, 95% CI = 0.986 - 0.984, P < 0.001) as independent predictors of AHRE. Conclusion: The study findings indicated that plasma levels of NT-proBNP, MDA, nitric oxide, and the expression of iNOS and eNOS were significantly associated with AHRE. Moreover, elevated plasma MDA concentrations, increased iNOS activity, and decreased eNOS activity were identified as independent predictors of AHRE. |
| Anahtar Kelimeler |
| Atrial high rate episodes | endothelial nitric oxide synthase | inducible nitric oxide synthase | malondialdehyde | nitric oxide |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY |
| Dergi ISSN | 1016-5169 |
| Dergi Tarandığı Indeksler | ESCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2024 |
| Cilt No | 52 |
| Sayı | 2 |
| Sayfalar | 81 / 87 |
| Doi Numarası | 10.5543/tkda.2023.07433 |
| Makale Linki | http://dx.doi.org/10.5543/tkda.2023.07433 |
| Atıf Sayıları | |
| WoS | 1 |
| SCOPUS | 1 |
| Google Scholar | 1 |
