| Yazarlar (7) |
Abdussamed Vural
Niğde Ömer Halisdemir Üniversitesi, Türkiye |
Prof. Dr. Mahmut KARAPEHLİVAN
Kafkas Üniversitesi, Türkiye |
|
Turgut Dolanbay
Niğde Ömer Halisdemir Üniversitesi, Türkiye |
|
Mustafa Oğuz Cumaoğlu
Türkiye |
|
Ahmet Yunus Hatip
T.C. Sağlık Bakanlığı, Türkiye |
|
Yakup Çetinkaya
Türkiye |
|
Adnan Ünalan
Niğde Ömer Halisdemir Üniversitesi, Türkiye |
| Özet |
| Objectives: This pilot study aimed to evaluate the efficacy of the 4-h mean lactate clearance (LACclr) level as a predictive factor for in-hospital outcomes, 30-day mortality, and treat- ment success in patients with acute cardiogenic pulmonary edema (ACPE), a significant clinical form of acute heart failure (AHF). Methods: A total of 44 patients diagnosed with acute pul- monary edema were included in the study. The patients were divided into two groups based on lactate levels and negative outcomes, and lactate and LACclr levels and nega- tive outcomes were analyzed using statistical tests such as Fisher’s exact test, Student’s t-test, Mann-Whitney U test, and Receiver operating characteristic (ROC) analysis. Results: The results indicated a statistically significant difference in the total hospitalization length of stay according to whether the patients had a negative outcome (intubation and in-hospital mortality) (p=0.033). Additionally, the area under the curve (AUC) value for 4-h mean LACclr was 0.795 in all patients, which was statistically significant in pre- dicting 30-day mortality (p=0.033). The optimal cut-off value for the 4-h mean LACclr in predicting 30-day mortality was found to be 5.57 %, with 80 % sensitivity and 66.7 % specificity. The threshold to rule out 30-day mortality for all patients was 18.85 with 100 % sensitivity and 30.2 % specificity (AUC, 0.795 95 % CI [0.546–1.000], p=0.033). Conclusions: These findings suggest that the 4-h LACclr level, calculated within 4 h of emergency department (ED) presentation, can be used as a predictive indicator for needing intubation, in-hospital mortality, and 30-day mor- tality and to identify patients at higher risk for adverse outcomes. |
| Anahtar Kelimeler |
| acute heart failure | acute pulmonary edema | cardiogenic | lactate | lactate clearance | prognosis |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Türk Biyokimya Dergisi |
| Dergi ISSN | 1303-829X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2024 |
| Cilt No | 49 |
| Sayı | 3 |
| Sayfalar | 401 / 409 |
| Doi Numarası | 10.1515/tjb-2023-0255 |
| Makale Linki | http://dx.doi.org/10.1515/tjb-2023-0255 |
| Atıf Sayıları |
