Effects of chrysin in cadmium-induced testicular toxicity in the rat; role of multi-pathway regulation
Yazarlar (5)
Doç. Dr. Sibel Çiğdem Tuncer Türkiye
Sefa Küçükler Türkiye
Doç. Dr. Cihan Gür Türkiye
Doç. Dr. Serpil AYGÖRMEZ Kafkas Üniversitesi, Türkiye
Prof. Dr. Fatih Mehmet Kandemir Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | MOLECULAR BIOLOGY REPORTS (Q3) | ||
| Dergi ISSN | 0301-4851 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2023 |
| Cilt / Sayı / Sayfa | 50 / 10 / 8305–8318 | DOI | 10.1007/s11033-023-08715-8 |
| Makale Linki | https://link.springer.com/article/10.1007/s11033-023-08715-8 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| Cadmium (Cd) is a strong toxic agent and causes serious damage to testicular tissues. Chrysin (CHR) is a natural flavonoid with many effective properties, especially antioxidant, anti-inflammatory and anti-apoptotic properties. The current study describes new evidence for the ameliorative effects of CHR on oxidative stress, apoptosis, autophagy and inflammation pathways in Cd-induced testicular tissue toxicity. Thirty-five male Wistar rats were divided into five groups, control, Cd, CHR, Cd + CHR25, and Cd + CHR50. Cd was administered alone at a dose of 25 mg/kg body weight or in combination with CHR 25 mg/kg and CHR 50 mg/kg for 7 days. Cd and CHR were administered orally. Biochemical, molecular, and histological methods were used to investigate inflammation, apoptosis, autophagy, and oxidant pathways in testicular tissue. Cd increased lipid peroxidation, JAK-2/STAT-3 levels, inflammation-related NF-κB, TNF-α, IL-1β, IL-6, COX-2, and iNOS levels, AKT-2, FOXO1, Bax, Apaf-1 and Caspase-3 levels, autophagic Beclin-1, LC3A and LC3B. The Cd also caused a decrease in the activities of antioxidant enzymes and GSH levels, antiapoptotic Bcl-2 levels. CHR, on the other hand, had the opposite effect of all these Cd-induced changes. Overall, the data of this study indicate that testicular damage associated with Cd toxicity could be ameliorated by CHR administration. |
| Anahtar Kelimeler |
| Testicular toxicology | Apoptosis | Inflammation | Cadmium | Oxidative stress | Chrysin |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 18 |