| Yazarlar |
Zahraa S. Al-Garawi
|
|
Ahmad H. Ismail Al-Qaisi
|
|
Kawthar Amer Al-Shamari
|
Doç. Dr. Füreya Elif ÖZTÜRKKAN
Türkiye |
Prof. Dr. Hacali NECEFOĞLU
Türkiye |
| Özet |
| Green synthesis of metal oxides as a treatment for bone diseases is still exploring. Herein, MgO and Fe2O3 NPs were prepared from the extract of Hibiscus sabdariffa L. to study their effect on vit D3, Ca+2, and alkaline phosphatase enzyme ALP associated with osteoporosis. Computational chemistry was utilized to gain insight into the possible interactions. These oxides were characterized by X-ray diffraction, SEM, FTIR, and AFM. Results revealed that green synthesis of MgO and Fe2O3 NPs was successful with abundant. MgO NPs were in vitro applied on osteoporosis patients (n = 35) and showed a significant elevation of vit D3 and Ca+2 (0.0001 > p < 0.001) levels, compared to healthy volunteers (n = 25). Thus, Hibiscus sabdariffa L. is a good candidate to prepare MgO NPs, with a promising enhancing effect on vit D3 and Ca+2 in osteoporosis. In addition, interactions of Fe2O3 and MgO NPs with ALP were determined by molecular docking study. Graphical abstract: (Figure presented.) |
| Anahtar Kelimeler |
| Fe2O3 NPs | Molecular docking | Green synthesis | MgO NPs | Osteoporosis | Hibiscus sabdariffa L. |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BIOPROCESS AND BIOSYSTEMS ENGINEERING |
| Dergi ISSN | 1615-7591 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 05-2024 |
| Cilt No | 47 |
| Sayı | 5 |
| Sayfalar | 753 / 766 |
| Doi Numarası | 10.1007/s00449-024-03012-5 |
| Makale Linki | http://dx.doi.org/10.1007/s00449-024-03012-5 |
| Atıf Sayıları |
