| Yazarlar (7) |
Arzu Gezer
Atatürk Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Şükran YEDİEL ARAS
Kafkas Üniversitesi, Türkiye |
|
Nurcan Kılıç Baygutalp
Türkiye |
Prof. Dr. Ebru KARADAĞ SARI
Kafkas Üniversitesi, Türkiye |
|
Gursel Bedir
|
|
Behzad Mokhtare
Türkiye |
|
Kadriye Yılmaz
Kafkas Üniversitesi, Türkiye |
| Özet |
| In this study, the effects of vitamin D (Vit. D) and a stinging nettle [ L. (UD)] extract were examined using histopathological and immunohistochemical methods in the stomach tissues of an experimentally created rat model of Crohn's disease (CD). The CD model was created using trinitrobenzene sulfonic acid (TNBS). The animals in the study were divided into control, TNBS, TNBS+Vit. D, and TNBS+UD groups. At the end of the experiment, the animals were euthanised and their stomach tissues were evaluated for necrosis, degeneration, apoptosis, and inflammation. Additionally, an immunohistochemical method was applied to determine the somatostatin (SSTR), aquaporin-1 (AQP-1), caspase-3, and tumour necrosis factor-alpha (TNF-α) immunoreactivity in the gastric tissues. In the evaluations, degenerative and necrotic changes and mononuclear cell infiltration areas were observed in the TNBS group, but such changes could be improved with Vit. D and UD applications. The results suggest that the combination of the Vit. D and UD extract may have a protective and therapeutic role in mitigating TNBS-induced damage to the gastric tissues, potentially through the regulation of SSTR, AQP-1, caspase-3, and TNF-α expression. This indicates a promising avenue for further research and the exploration of these compounds in the context of gastrointestinal health. |
| Anahtar Kelimeler |
| aquaporin-1 | Crohn's disease | somatostatin | TNF-alpha |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Veterinarni Medicina |
| Dergi ISSN | 0375-8427 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2024 |
| Cilt No | 69 |
| Sayı | 3 |
| Sayfalar | 84 / 93 |
| Doi Numarası | 10.17221/111/2023-VETMED |
| Makale Linki | https://doi.org/10.17221/111/2023-VETMED |
| Atıf Sayıları | |
| WoS | 1 |
