| Yazarlar (9) |
Timor Omar
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Yavuz KARABAĞ
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Metin ÖĞÜN
Türkiye |
Doç. Dr. İnanç ARTAÇ
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Muammer KARAKAYALI
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Doğan İLİŞ
Kafkas Üniversitesi, Türkiye |
|
Ayça Arslan
Türkiye |
|
Cihan Dündar
Türkiye |
Prof. Dr. İbrahim RENCÜZOĞULLARI
Kafkas Üniversitesi, Türkiye |
| Özet |
| Aims The current study aimed to investigate the relationship between homocysteine and no-reflow phenomenon in patients undergoing primary percutaneous coronary intervention (pPCI). Methods Patients with ST-elevation myocardial infarctions (STEMI) who underwent pPCI in our center between May 01, 2022, and 20 August 2023 were included in this cross-sectional observational study. Patients were classified into two groups according to the occurrence of no-reflow during pPCI. Findings were compared between the two groups. Results A total of 332 patients [male, 75 (%82.8)] with STEMI undergoing pPCI, were included. Among them, 35 (10.5%) patients developed no-reflow. Homocysteine level was significantly higher in the no-reflow(+) group than the no-reflow(-) group [median (IQR), 19.02 (16.11-22.23 vs. 12.45 (10.99-14.93), p=0.019]. According to the multivariate analysis, homocysteine level, TIMI risk score, and postdilatation were independent predictors of no-reflow occurrence [Odds Ratio (95% CI), 1.127 (1.042-1.218), p=0.003, 1.385 (1.157-1.659), p<0.001, and 2.396 (1.092-5.257), p=0.029, respectively]. Considering the ROC curve analysis for homocysteine predicting no-reflow, the area under the curve (AUC) was 0.714 with an optimal cut-off value of 14.1 (sensitivity of 71%, specificity 62%). Conclusion Higher admission homocysteine levels were associated with no-reflow development in STEMI patients during pPCI. Higher levels of homocysteine may identify a subset of patients at a higher risk of no-reflow development during pPCI. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale |
| Dergi Adı | Journal of Health Sciences and Medicine |
| Dergi ISSN | 2636-8579 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | Türkçe |
| Basım Tarihi | 03-2024 |
| Cilt No | 7 |
| Sayı | 2 |
| Sayfalar | 199 / 205 |
| Doi Numarası | 10.32322/jhsm.1413552 |
| Makale Linki | http://dx.doi.org/10.32322/jhsm.1413552 |
| Atıf Sayıları | |
| Google Scholar | 2 |
