Acute Phase Response and Acute Phase Proteins in Animalis (Current Multidisciplinary Studies in Veterinary Medicine 1)
Yazarlar (2)
Prof. Dr. Oğuz MERHAN Kafkas Üniversitesi, Türkiye
Prof. Dr. Kadir BOZUKLUHAN Kafkas Üniversitesi, Türkiye
| Bölüm Adı | Acute Phase Response and Acute Phase Proteins in Animalis | ||
| Kitap Adı | Current Multidisciplinary Studies in Veterinary Medicine 1 | ||
| Bölüm Sayfaları | 3-34 | ||
| Kitap Türü | Kitap Bölümü | ||
| Kitap Alt Türü | Alanında uluslararası yayınlanan kitap bölümü | ||
| Kitap Niteliği | Diğer uluslararası bilimsel kitap | ||
| Kitap Dili | İngilizce | Basım Tarihi | 01-2022 |
| DOI Numarası | – | ISBN | 978-625-8323-21-4 |
| Basıldığı Ülke | Türkiye | Basıldığı Şehir | Ankara |
| Kitap Linki | www.iksadyayinevi.com | ||
| UAK Araştırma Alanları |
Veterinerlik İç Hastalıkları
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| Özet |
| Acute phase proteins (APP) are known as a group of proteins whose concentrations increase (positive APP) or decrease (negative APP) in the blood in inflammation, infection, tissue damage, neoplastic developments and some immunological diseases occurring in the organism (Gruys et al., 1994; Petersen et al., 2004).During the disease, a physiological defense reaction occurs in the organism, which restores homeostasis and prevents microbial growth. In this reaction, which is called the acute phase response (APR), a local response occurs in the diseased body area and some mediators are released into the environment. Many different reactions such as fever, anorexia, leukocytosis, increased secretion of glucocorticoids, increased blood flow to the inflamed area, activation of the complement system, clot formation, decreased serum Ca, Zn, Fe, vitamin A levels, negative nitrogen balance, and changes in the concentration of some plasma proteins develop in these mediators by activating receptors on different cell (Whicher et al., 1991; Gruys et al., 1994; Gruys et al., 2005a). APP are species specific and although their diagnostic importance varies by animal species, while the serum level of positive APP (pAPP) such as haptoglobin, ceruloplasmin, and fibrinogen increases due to APR, the level of negative APP (nAPP) such as albumin, prealbumin and transferrin decreases (Murata et al., 2004; Gökçe and Bozukluhan, 2009). |
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