| Yazarlar |
Doç. Dr. Damla BİNNETOĞLU
Kafkas Üniversitesi, Türkiye |
Feyza Arıcıoğlu
Marmara Üniversitesi, Türkiye |
|
Halil Özcan
Atatürk Üniversitesi, Türkiye |
|
Ufuk Okkay
Atatürk Üniversitesi, Türkiye |
|
Ahmet Hacımüftüoğlu
Atatürk Üniversitesi, Türkiye |
| Özet |
| Objective: We aimed to indicate the relationship between depression and glutamate, and to reveal the effect of escitalopram, an antidepressant,which is widely used in depression treatment and reuptake parameters of glutamate, and to treat depression with ceftriaxone, one of the betalactam antibiotics which increased the number and activity of glutamate transporters.Methods: In CUMS, rats subjected to series of different mild stressors in an unpredictable manner for 40 days. On the day 20 rats were divided in togroups such as CUMS, CUMS+Escitalopram and CUMS+Ceftriaxone. 4 weeks. Treatments were started at 2nd week of CUMS and continued for 21days. Anhedonia and antidepressant effect were assessed by sucrose preference (SP), locomotor activity (LA), elevated plus maze (EPM) and forcedswim test (FST) at the end of the experiment respectively. At the end of the experiment, behavioral tests were made, and glutamate reuptake timein CA3 (cornuammonis 3) brain region which are related with depression were measured by means of in vivo voltammetry technique.Results: Ceftriaxone treatment had an antidepressant-like effect. Escitalopram and ceftriaxone increased SP and locomotor activity, reducedimmobility FST, forced swim and time spent in closed arms in EPM compared to CUMS group. In this in-vivo voltametric study, it was also observedthat there was a significant decrease in glutamate reuptake time in depression.Conclusion: Escitalopram and ceftriaxone demonstrated antidepressant-like effects by reversing behavioral changes in CUMS model. Escitalopramtreatment in CA3 region corrected the decrease in glutamate reuptake time which is consistent with the hypothesis that enhanced uptake ofglutamate might have antidepressant-like effects. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | Clinical and Experimental Health Sciences |
| Dergi ISSN | 2459-1459 |
| Dergi Tarandığı Indeksler | ESCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2019 |
| Cilt No | 9 |
| Sayı | 4 |
| Sayfalar | 294 / 299 |
| Doi Numarası | 10.33808/clinexphealthsci.613963 |
| Makale Linki | https://dergipark.org.tr/tr/doi/10.33808/clinexphealthsci.613963 |
| Atıf Sayıları |
