| Yazarlar |
Dr. Öğr. Üyesi Muammer KARAKAYALI
Kafkas Üniversitesi, Türkiye |
Metin Ogun
Kafkas Üniversitesi, Turkey |
|
Inanç Artac
Kafkas Üniversitesi, Turkey |
|
Doǧan Ilis
Kafkas Üniversitesi, Turkey |
|
Ayca Arslan
Kafkas Üniversitesi, Turkey |
|
Timor Omar
Kafkas Üniversitesi, Turkey |
|
Öztürk Demir
Kafkas Üniversitesi, Turkey |
|
Talha Karahan
Kafkas Üniversitesi, Turkey |
|
Soner Kina
Kafkas Üniversitesi, Turkey |
|
Ibrahim Rencuzogullari
Kafkas Üniversitesi, Turkey |
|
Yavuz Karabag
Kafkas Üniversitesi, Turkey |
| Özet |
| Introduction and objective Malondialdehyde (MDA) is a predictive marker of cardiovascular events in patients with stable angina pectoris. However, there is limited information available regarding this marker in patients with acute coronary syndrome (ACS). The aim of the study was to explore the association of MDA levels with inhospital mortality among patients with ACS. Materials and Methods The study sample consisted of 556 ACS patients. The leftover plasma samples collected in EDTA vials for troponin T estimation within 24 h of chest pain were used for analysis. Blood samples were collected into tubes for MDA, nitric oxide (NO), inducible nitric oxide synthase (i-NOS), endothelial nitric oxide synthase (e-NOS), total sialic acid (TSA), NT-proBNP, ANP, homocysteine, and cardiac troponin I (cTnI). The blood samples were centrifuged (4000g, 4 °C) for 10 min, and the obtained serum then kept at -25 °C until the analyses were carried out. The relationship between these markers and inhospital mortality of ACS patients was investigated. Results Univariate logistic regression analysis revealed significant correlations among sex, age, creatine, MDA, NT-proBNP, ANP, homocysteine, cTnI, NO, e-NOS, i-NOS, and TSA. Further analysis of these variables using the multivariate logistic regression analysis indicated that age, creatine, MDA, and NT-proBNP were independent predictors. Optimal MDA cutoff value of >33.1 predicted inhospital mortality with 85% sensitivity and 88.17% specificity [AUC: 0.905 (95% CI: 0.878-0.928, P < 0.001)]. Conclusion We demonstrated that MDA levels were elevated in cases of inhospital mortality among ACS patients and the optimal MDA cutoff value of >33.1 predicted inhospital mortality with 85% sensitivity and 88.17% specificity. |
| Anahtar Kelimeler |
| acute coronary syndrome | coronary artery disease | malondialdehyde | mortality |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Coronary Artery Disease |
| Dergi ISSN | 0954-6928 |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2024 |
| Sayı | 1 |
| Doi Numarası | 10.1097/MCA.0000000000001469 |
| Atıf Sayıları |
