Influence of topical NPH-insulin use on wound healing and oxidative stress in alkali corneal burns: an experimental study in a rabbit model
Yazarlar (6)
Prof. Dr. Başak KURT Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Lokman Balyen Türkiye
Prof. Dr. Onur ATAKİŞİ Kafkas Üniversitesi, Türkiye
Doç. Dr. Serdar YİĞİT Kafkas Üniversitesi, Türkiye
Doç. Dr. Uğur AYDIN Kafkas Üniversitesi, Türkiye
Prof. Dr. İsa ÖZAYDIN Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | IRANIAN JOURNAL OF VETERINARY RESEARCH (Q3) | ||
| Dergi ISSN | 1728-1997 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2024 |
| Cilt / Sayı / Sayfa | 25 / 3 / 202–209 | DOI | 10.22099/ijvr.2024.47545.6867 |
| UAK Araştırma Alanları |
Veteriner Biyokimyası
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| Özet |
| Background In acute alkali corneal burns, the routine treatment protocol includes suppressing inflammation using corticosteroids. In recent years, there has been a growing interest in the role of insulin in wound healing research due to its remarkable positive effects. Aims The present study aimed to compare the healing effects of dexamethasone -the conventional approach- and NPH-insulin on alkali corneal burns. Methods An alkali corneal burn was created using Ca (OH)2 in all subjects. One group (n=6) was treated with an ophthalmic ointment containing dexamethasone (group I), and another group (n=6) was treated with an insulin ointment (group II). The control group (n=6) received no treatment (group III). Clinical changes in the corneal burn areas were monitored on days 3, 7, 14, and 21. The animals were euthanized on day 21. The excised corneas were examined for histopathological … |
| Anahtar Kelimeler |
| Corneal alkali burn | Insulin | Oxidative stress | Rabbit | Wound healing |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |