| Yazarlar (5) |
Prof. Dr. Emine ATAKİŞİ
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Onur ATAKİŞİ
Kafkas Üniversitesi, Türkiye |
Öğr. Gör. Melek ÖZTÜRKLER DÜNDAR
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Kezban YILDIZ DALGINLI
Kafkas Üniversitesi, Türkiye |
Öğr. Gör. Çağatay ÖZBEY
Kafkas Üniversitesi, Türkiye |
| Özet |
| Aluminum (Al), one of the three most prevalent metals in the Earth's crust, adversely impacts all metabolic systems of living organisms due to its extensive utilization by humans. It is known that omega-3 fatty acids (ω-3FA) protect the organism against diseases and have positive effects on the immune system. The aim of the study was to investigate the effect of ω-3FA on 8-OH-2-deoxyguanosine (8-OHdG), glutathione (GSH) levels and adenosine deaminase (ADA), paraoxonase (PON), and catalase (CAT) activities in rats with acute aluminum toxicity. The study also aimed to investigate the antioxidant system, as well as Al, zinc (Zn), and iron (Fe) levels. Forty Sprague-Dawley rats (n = 40) were used in the study and the rats were divided into four equal groups (n = 10). In group I, 0.5 mL of 0.9% saline solution (NaCI) was injected intraperitoneally. Group II was injected with 34 mg/kg aluminum chloride (AlCI) intraperitoneally. Group III received 400 mg/kg ω-3FA for 7 days and group IV received both AlCI and 400 mg/kg ω-3FA for 7 days. At the end of the study, blood samples were obtained by cardiac puncture. The findings showed that Al exposure increased serum 8-OHdG and total oxidant status (TOS) levels, as well as ADA activity, which are markers associated with oxidative damage. Conversely, PON and CAT activities, GSH, and total antioxidant status (TAS) levels decreased compared to the control group. Furthermore, Zn and Fe levels decreased as Al levels increased. In conclusion, Al has the capacity to induce oxidative damage and lipid peroxidation, while ω-3 fatty acids may mitigate this damage through a regulatory mechanism. Moreover, ω-3-FA could be used as a therapeutic agent that reduces Al toxicity. |
| Anahtar Kelimeler |
| Aluminum | Omega-3 fatty acids | Heavy metals | Rat | Toxicity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Biological Trace Element Research |
| Dergi ISSN | 0163-4984 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2024 |
| Cilt No | 10 |
| Sayı | 4 |
| Sayfalar | 1 / 10 |
| Doi Numarası | 10.1007/s12011-024-04402-2 |
| Makale Linki | https://doi.org/10.1007/s12011-024-04402-2 |
| Atıf Sayıları |
