Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells
Yazarlar (6)
Doç. Dr. Ali YEŞİLDAĞ Kafkas Üniversitesi, Türkiye
Halime Topal Kızıloğlu
Erzurum Technical University, Türkiye
Erzurum Technical University, Türkiye
Ebubekir Dirican Bilecik Şeyh Edebali Üniversitesi, Türkiye
Doç. Dr. Elif Erbaş Atatürk Üniversitesi, Türkiye
Doç. Dr. Volkan GELEN Kafkas Üniversitesi, Türkiye
Prof. Dr. Adem Kara Erzurum Technical University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Biological Trace Element Research (Q2) | ||
| Dergi ISSN | 0163-4984 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2024 |
| Cilt / Sayı / Sayfa | 202 / 10 / 4494–4507 | DOI | 10.1007/s12011-024-04090-y |
| Makale Linki | https://doi.org/10.1007/s12011-024-04090-y | ||
| UAK Araştırma Alanları |
Analitik Kimya
Elektrokimya
Yüzey Kimyası
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| Özet |
| Metformin is commonly prescribed to people with diabetes. Metformin has been shown in previous studies to be able to prevent the growth of cancer cells. This study aims to investigate the effects of metformin and gold nanoparticles in MCF7 breast cancer and A549 lung cell lines. The effects of metformin and gold nanoparticles on MCF7 breast cancer and A549 lung cells were determined on cells grown in 24 h cell culture. MCF-7 and A549 cells were incubated for 24 h with the treatment of escalating molar concentrations of ifosfamide. The MTT assay was used to determine the cytotoxicity of metformin toward MCF7 and A549 cell lines. The expression of Bax, BCL2, PI3K, Akt3, mTOR, Hsp60, Hsp70, and TNF-α was measured by RT-PCR. Metformin and gold nanoparticles inhibited the proliferation of MCF-7 and A549 cells in a dose and time-dependent manner with an IC50 value of 5 µM and 10 µg/mL. RT-PCR … |
| Anahtar Kelimeler |
| A549 | Cell Cytotoxicity | Gold Nanoparticles | Ifosfamide | MCF7 | Metformin |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 11 |
| Google Scholar | 13 |