Silver Nanoparticles Loaded with Oleuropein Reduce Doxorubicin-Induced Testicular Damage by Regulating Endoplasmic Reticulum Stress, and Apoptosis
Yazarlar (7)
Doç. Dr. Elif Erbaş Atatürk Üniversitesi, Türkiye
Doç. Dr. Volkan GELEN Kafkas Üniversitesi, Türkiye
Doç. Dr. Hülya Kara Atatürk Üniversitesi, Türkiye
Doç. Dr. Semin Gedikli Atatürk Üniversitesi, Türkiye
Doç. Dr. Ali YEŞİLDAĞ Kafkas Üniversitesi, Türkiye
Doç. Dr. Seçkin Özkanlar Atatürk Üniversitesi, Türkiye
Doç. Dr. Serkan Ali Akarsu Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Biological Trace Element Research (Q2) | ||
| Dergi ISSN | 0163-4984 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2024 |
| Cilt / Sayı / Sayfa | 202 / 10 / 4687–4698 | DOI | 10.1007/s12011-024-04058-y |
| Makale Linki | https://doi.org/10.1007/s12011-024-04058-y | ||
| UAK Araştırma Alanları |
Analitik Kimya
Elektrokimya
Yüzey Kimyası
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| Özet |
| Doxorubicin (DOX) is the most used chemotherapeutic agent for treating solid tumors. DOX treatment may lead to testicular damage using oxidative stress, resulting in infertility. These adverse effects may be prevented by the activation of antioxidant systems.Oleuropein (OLE) is a powerful flavonoid with several ameliorative effects, including antioxidative, antiproliferative, and anti-inflammatory. It would be more efficient and applicable in treating chronic human diseases if its poor bioavailability improves with a nano-delivery system. The current study aims to assess the histopathological changes and antioxidative effects of OLE loaded with silver nanoparticles oleuropein (OLE-AgNP) on the testicular injury triggered by DOX in rats.Forty-eight male albino rats were randomly divided into six groups as follows: the control, DOX (2.5 mg/kg), OLE (50 mg/kg), AgNP (100 mg/kg), OLE + AgNP (50 mg/kg), OLE (50 mg/kg … |
| Anahtar Kelimeler |
| Apoptosis | Endoplasmic reticulum-stress | Inflammation | Oleuropein | Silver nanoparticles |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 33 |
| Google Scholar | 37 |