Syringic acid loaded silver nanoparticles protects ovarian ischemia-reperfusion injury in rats by inhibiting endoplasmic reticulum stress-mediated apoptosis
Yazarlar (5)
Doç. Dr. Elif Erbaş Atatürk Üniversitesi, Türkiye
Doç. Dr. Seçkin Özkanlar Atatürk Üniversitesi, Türkiye
Doç. Dr. Ali YEŞİLDAĞ Kafkas Üniversitesi, Türkiye
Prof. Dr. Adem Kara Erzurum Technical University, Türkiye
K.J. Senthil Kumar
National Chung Hsing University, Tayvan
National Chung Hsing University, Tayvan
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Drug Delivery Science and Technology (Q1) | ||
| Dergi ISSN | 1773-2247 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 09-2024 |
| Cilt / Sayı / Sayfa | 99 / 1 / 105944–105944 | DOI | 10.1016/j.jddst.2024.105944 |
| Makale Linki | https://doi.org/10.1016/j.jddst.2024.105944 | ||
| UAK Araştırma Alanları |
Analitik Kimya
Elektrokimya
Yüzey Kimyası
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| Özet |
| In the present study, we investigated the protective effect of syringic acid (SA) loaded silver nanoparticles (AgNPs) on endoplasmic reticulum stress-mediated apoptosis during ovarian ischemia-reperfusion injury (IR) in rats. Initial UV–Vis and FT-IR analysis revealed the presence of the Ag and SA in the SA-AgNPs, respectively. TEM analysis demonstrated the spherical morphology with 10–50 nm of nanoparticle size. Next, we evaluated the protective effect of SA-AgNPs against IR. 15-weeks-old rats were divided into seven groups, as follows: control, AgNPs, SA, IR, AgNPs + IR, SA + IR, and SA + AgNPs + IR. Induction of IR led to a significant increase in apoptotic markers (caspase-3), pro-inflammatory markers (IL-1β, TNF-α, ATF-6, NF- κB-p65, and P2X7R), and endoplasmic reticulum stress marker (IRE1) in ovary tissue. Additionally, a remarkable increase in serum IL-1β and TNF-α were found. Moreover, an … |
| Anahtar Kelimeler |
| Endoplasmic reticulum stress | Ovarian ischemia-reperfusion injury | Ovary tissues | Silver nanoparticles | Syringic acid |
Science Direct
Syringic acid loaded silver nanoparticles protects ovarian ischemia-reperfusion injury in rats by inhibiting endoplasmic reticulum stress-mediated apoptosis
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| Atıf Sayıları | |
| Scopus | 4 |
| Google Scholar | 7 |